Journal ArticleDOI
Gene-gene interaction between MAOA and COMT in suicidal behavior: analysis in schizophrenia.
Vincenzo De Luca,Subi Tharmalingam,Daniel J. Müller,Daniel J. Müller,Greg W.H. Wong,Andrea de Bartolomeis,James L. Kennedy +6 more
TLDR
The results suggest that epistasis between MAOA and COMT genes may not influence suicidal behavior in patients with schizophrenia.About:
This article is published in Brain Research.The article was published on 2006-06-30. It has received 44 citations till now. The article focuses on the topics: Catechol-O-methyl transferase & Gene interaction.read more
Citations
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Journal ArticleDOI
Suicide and schizophrenia: a systematic review of rates and risk factors
Kahyee Hor,Matthew Taylor +1 more
TL;DR: A systematic review of all original studies concerning suicide in schizophrenia published since 2004 found that number of prior suicide attempts, depressive symptoms, active hallucinations and delusions, and the presence of insight all had a strong evidential basis.
Journal ArticleDOI
Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study
Raffaella Calati,Stefano Porcelli,Ina Giegling,Annette M. Hartmann,Hans-Jürgen Möller,Diana De Ronchi,Alessandro Serretti,Dan Rujescu +7 more
TL;DR: Evidence of a COMT role in the modulation of personality traits has been found, suggested that COMT variants may not be directly implicated in suicidal behavior, however evidence of an association between rs4633 and Reward Dependence and rs737865 and Angry Reaction is found.
Journal ArticleDOI
The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT
Bennard Doornbos,D.A. Janneke Dijck-Brouwer,Ido P. Kema,Marit A. C. Tanke,Saskia A. van Goor,Frits A. J. Muskiet,Jakob Korf +6 more
TL;DR: MAOA in combination with COMT appears to regulate not only the stress response in laboratory experiments, but also seems to influence the stress-evoked onset of mood during normal, mild, stressful events, such as experienced in the peripartum period.
Journal ArticleDOI
The genetics of suicide: a critical review of molecular studies.
TL;DR: The authors conclude that future research may benefit from using a more systematic and comprehensive selection of candidate genes and variants, examining gene-environment and gene-gene interactions, and investigating higher-order moderators.
Journal ArticleDOI
The role of the serotonergic system at the interface of aggression and suicide.
TL;DR: The development of animal models that may capture the complexity of 5-HT-ergic interactions promises to afford a powerful tool to elucidate the pathophysiology of impulsive aggression and suicidability, and identify new effective therapies for these conditions.
References
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Book
Statistical Methods for Meta-Analysis
Larry V. Hedges,Ingram Olkin +1 more
TL;DR: In this article, the authors present a model for estimating the effect size from a series of experiments using a fixed effect model and a general linear model, and combine these two models to estimate the effect magnitude.
Journal ArticleDOI
Statistical Methods for Meta-Analysis.
TL;DR: In this paper, the authors present a model for estimating the effect size from a series of experiments using a fixed effect model and a general linear model, and combine these two models to estimate the effect magnitude.
Journal ArticleDOI
Role of Genotype in the Cycle of Violence in Maltreated Children
Avshalom Caspi,Avshalom Caspi,Joseph L. McClay,Terrie E. Moffitt,Terrie E. Moffitt,Jonathan Mill,Judy Martin,Ian W. Craig,Alan Taylor,Richie Poulton +9 more
TL;DR: In this paper, a large sample of male children from birth to adulthood was studied to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not.
Journal ArticleDOI
A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies
TL;DR: The procedure reported here is the most economical, safe and rapid for preparation of DNA from whole blood and eliminates completely the use of proteinase K treatment.
Journal ArticleDOI
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Herbert M. Lachman,Demitri F. Papolos,Takuya Saito,Yue Min Yu,Carol L. Szumlanski,Richard M. Weinshilboum +5 more
TL;DR: The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.