Genetic Liability to Rheumatoid Arthritis in Relation to Coronary Artery Disease and Stroke Risk
TLDR
To assess the causality of the associations of rheumatoid arthritis with coronary artery disease (CAD) and stroke using the Mendelian randomization approach, a large number of patients with RA were diagnosed with at least some form of arthritis.Abstract:
To assess the causality of the associations of rheumatoid arthritis (RA) with coronary artery disease (CAD) and stroke using the Mendelian randomization approach.read more
Citations
More filters
Journal ArticleDOI
Rheumatoid arthritis and risk of site-specific cancers: Mendelian randomization study in European and East Asian populations
Shuai Yuan,Jie Chen,Xixian Ruan,Mathew Vithayathil,Siddhartha Kar,Xia Li,Amy M. Mason,Stephen Burgess,Susanna C. Larsson +8 more
TL;DR: In this article , the associations of rheumatoid arthritis (RA) with risk of site-specific cancers beyond lymphohematopoietic cancer have been extensively explored.
Journal ArticleDOI
The causal effect of physical activity intensity on COVID-19 susceptibility, hospitalization, and severity: Evidence from a mendelian randomization study
TL;DR: In this article , a Mendelian randomization (MR) study was performed to verify the causal influence of light and moderate-to-vigorous PA on COVID-19 susceptibility, hospitalization, and severity.
Journal ArticleDOI
The genetic contribution of inflammation to the increased risk of cardiovascular disease in rheumatoid arthritis.
TL;DR: In this paper , the authors present a method for the extraction of features from a set of features, which is then used to construct a model of the user's behavior. But they do not provide any supporting information for the model.
Journal ArticleDOI
Causal relationship between Type 1 diabetes and osteoporosis and fracture occurrence: a two-sample Mendelian randomization analysis
Journal ArticleDOI
Is Rheumatoid Arthritis a Causal Factor in Cardiovascular Disease?
TL;DR: Traditional risk factors for CVD do not fully explain the elevated risk in RA, and Yuan et al address the question whether the pathogenesis of rheumatoid arthritis is related to CVD.
References
More filters
Journal ArticleDOI
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.
Frank C. Arnett,Steven M. Edworthy,Daniel A. Bloch,Dennis J. McShane,James F. Fries,Norman S. Cooper,L. A. Healey,Stephen R. Kaplan,Matthew H. Liang,Harvinder S. Luthra,Thomas A. Medsger,Donald M. Mitchell,David H. Neustadt,Robert S. Pinals,Jane G. Schaller,John T. Sharp,Ronald L. Wilder,Gene G. Hunder +17 more
TL;DR: The revised criteria for the classification of rheumatoid arthritis (RA) were formulated from a computerized analysis of 262 contemporary, consecutively studied patients with RA and 262 control subjects with rheumatic diseases other than RA (non-RA).
Journal ArticleDOI
European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012)
Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Y.M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W M Monique Verschuren +25 more
TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
Journal ArticleDOI
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja-Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Yvo M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W. M. Monique Verschuren +25 more
TL;DR: ABI is ankle-brachial (blood pressure) index and ABPM is ambulatory blood pressure monitoring as mentioned in this paper ; ACCORD is action to control cardiovascular risk in Diabetes and Vascular disease.
Journal ArticleDOI
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
TL;DR: An adaption of Egger regression can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is not subject to these violations, and provides a sensitivity analysis for the robustness of the findings from a Mendelian randomization investigation.
Journal ArticleDOI
An atlas of genetic correlations across human diseases and traits.
Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,Hilary K. Finucane,Verneri Anttila,Verneri Anttila,Alexander Gusev,Felix R. Day,Po-Ru Loh,Po-Ru Loh,Laramie E. Duncan,Laramie E. Duncan,John R. B. Perry,Nick Patterson,Elise B. Robinson,Elise B. Robinson,Mark J. Daly,Mark J. Daly,Alkes L. Price,Alkes L. Price,Benjamin M. Neale,Benjamin M. Neale +20 more
TL;DR: This work introduces a technique—cross-trait LD Score regression—for estimating genetic correlation that requires only GWAS summary statistics and is not biased by sample overlap, and uses this method to estimate 276 genetic correlations among 24 traits.