Genotyping of Helicobacter pylori virulence-associated genes shows high diversity of strains infecting patients in western Venezuela
Miguel Angel Chiurillo,Yeinmy Moran,Miryan Cañas,Elvis Valderrama,Nashdalish Granda,Marjorie Sayegh,José Luis Ramírez +6 more
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TLDR
Patients from the western region of Venezuela have an elevated prevalence of infection with H. pylori strains carrying known virulence genotypes with high genetic diversity, which highlights the importance of identifying gene variants for an early detection of virulent genotypes.About:
This article is published in International Journal of Infectious Diseases.The article was published on 2013-09-01 and is currently open access. It has received 30 citations till now. The article focuses on the topics: CagA & Helicobacter pylori.read more
Citations
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Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis
TL;DR: A review highlights the key findings of H. pylori virulence factors reported over the past 20 years and the development of large-scale screening methods, including proteomic, and transcriptomic tools, has been used to determine the complex gene regulatory networks in the bacterium.
Journal ArticleDOI
Clinical relevance of Helicobacter pylori virulence factors in Iranian patients with gastrointestinal diseases.
Nader Bagheri,Fatemeh Azadegan-Dehkordi,Mahmoud Rafieian-Kopaei,Ghorbanali Rahimian,Majid Asadi-Samani,Hedayatollah Shirzad +5 more
TL;DR: Clinical relevance of adhesion molecules and significant virulence factors of H. pylori in Iranian patients with gastrointestinal diseases are discussed in comparison to other countries.
Journal ArticleDOI
Clinical relevance of cagL gene and virulence genotypes with disease outcomes in a Helicobacter pylori infected population from Iran.
Abbas Yadegar,Ashraf Mohabati Mobarez,Masoud Alebouyeh,Tabassom Mirzaei,Terry Kwok,Mohammad Reza Zali +5 more
TL;DR: It is demonstrated that neither single genotype nor combination genotypes of virulence-associated genes was significantly helpful markers for predicting the severity of gastroduodenal disease associated with H. pylori infection in Iranian patients.
Journal ArticleDOI
Prevalence of Helicobacter pylori vacA, cagA, and iceA Genotypes in Cuban Patients with Upper Gastrointestinal Diseases.
Onelkis Feliciano,Oderay Gutiérrez,Lidunka Valdés,Trini Fragoso,Ana Maria Calderin,Antonio Eduardo Valdes,Rafael Llanes +6 more
TL;DR: A high prevalence of H. pylori virulent genotypes in Cuban patients over 40 years old while iceA2 alleles demonstrated a good specificity in patients with NUD is demonstrated.
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Environmental contributions to gastrointestinal and liver cancer in the Asia-Pacific region.
TL;DR: In the Asia–Pacific region, gastric, colorectal, and hepatocellular (liver) cancer show substantial regional variation in incidence consistent with the presence of important environmental factors, which are central to the development and implementation of effective cancer control programs for the region.
References
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Helicobacter pylori infection and the development of gastric cancer
Naomi Uemura,Sumika Okamoto,Susumu Yamamoto,Nobuyuki Matsumura,Shigeki Yamaguchi,Michio Yamakido,Kiyomi Taniyama,Noboyuki Sasaki,Ronald J Schlemper +8 more
TL;DR: Gastric cancer develops in persons infected with H. pylori but not in uninfected persons, and those with histologic findings of severe gastric atrophy, corpus-predominant gastritis, or intestinal metaplasia are at increased risk.
Journal Article
Infection with Helicobacter pylori Strains Possessing cagA Is Associated with an Increased Risk of Developing Adenocarcinoma of the Stomach
Martin J. Blaser,Guillermo I. Perez-Perez,Harry Kleanthous,Timothy L. Cover,Richard M. Peek,Po-Huang Chyou,Grant N. Stemmermann,Abraham M. Y. Nomura +7 more
TL;DR: It is concluded that infection with a cagA-positive H. pylori strain in comparison with acagA -negative strain somewhat increases the risk for development of gastric cancer, especially intestinal type affecting the distal stomach.
Journal ArticleDOI
Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori ASSOCIATION OF SPECIFIC vacA TYPES WITH CYTOTOXIN PRODUCTION AND PEPTIC ULCERATION
John Atherton,Ping Cao,Richard M. Peek,Murali K. R. Tummuru,Martin J. Blaser,Timothy L. Cover +5 more
TL;DR: Specific vacA genotypes of H. pylori strains are associated with the level of in vitro cytotoxin activity as well as clinical consequences, which implies that recombination has occurred in vivo between vacA alleles.
Journal ArticleDOI
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens
TL;DR: Bacteria did not bind to Leb antigen substituted with a terminal GalNAc alpha 1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.
Journal ArticleDOI
Traces of human migrations in Helicobacter pylori populations
Daniel Falush,Thierry Wirth,Bodo Linz,Jonathan K. Pritchard,Matthew Stephens,Mark Kidd,Martin J. Blaser,David Y. Graham,Sylvie Vacher,Guillermo I. Perez-Perez,Yoshio Yamaoka,Francis Mégraud,Kristina Otto,Ulrike Reichard,Elena Katzowitsch,Xiaoyan Wang,Mark Achtman,Sebastian Suerbaum +17 more
TL;DR: Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions.
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