Journal ArticleDOI
Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes.
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TLDR
The enhancement of glucose uptake in L6 rat skeletal muscle cells by the gingerol pungent principles of the ginger extract supports the potential of ginger and its pungents for the prevention and management of hyperglycemia and type 2 diabetes.Abstract:
In this study we investigate the active constituents of the rhizome of Zingiber officinale , Roscoe (ginger) and determine their activity on glucose uptake in cultured L6 myotubes and the molecular mechanism underlying this action. Freeze-dried ginger powder was extracted with ethyl acetate (1 kg/3 L) to give the total ginger extract, which was then separated into seven fractions, consisting of nonpolar to moderately polar compounds, using a short-column vacuum chromatographic method. The most active fraction (F7) was further purified for identification of its active components. The effect of the extract, fractions, and purified compounds on glucose uptake was evaluated using radioactive labelled 2-[1,2- 3 H]-deoxy-D-glucose in L6 myotubes. The pungent phenolic gingerol constituents were identified as the major active compounds in the ginger extract enhancing glucose uptake. ( S )-[6]-Gingerol was the most abundant component among the gingerols, however, ( S )-[8]-gingerol was the most potent on glucose uptake. The activity of ( S )-[8]-gingerol was found to be associated primarily with an increase in surface distribution of GLUT4 protein on the L6 myotube plasma membrane, as detected by expression of hemagglutinin epitope-tagged GLUT4 in L6 muscle cells. The enhancement of glucose uptake in L6 rat skeletal muscle cells by the gingerol pungent principles of the ginger extract supports the potential of ginger and its pungent components for the prevention and management of hyperglycemia and type 2 diabetes.read more
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Gingerols and shogaols: Important nutraceutical principles from ginger
Ruchi Badoni Semwal,Deepak Kumar Semwal,Sandra Combrinck,Alvaro M. Viljoen,Alvaro M. Viljoen +4 more
TL;DR: Significant evidence is highlighted indicating that these phenolic compounds could serve as important lead molecules for the development of therapeutic agents to treat various life-threatening human diseases, particularly cancer.
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The use of plants in the traditional management of diabetes in Nigeria: pharmacological and toxicological considerations.
TL;DR: A review of medicinal plants traditionally used for diabetes management in Nigeria and ways in which their therapeutic potential can be properly harnessed for possible integration into the country's healthcare system are highlighted.
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Ginger rhizomes (Zingiber officinale): A spice with multiple health beneficial potentials
TL;DR: The present treatise reviews all the experimentally validated health benefits of this spice, to make a claim on its nutraceutical application.
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Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review.
TL;DR: Ginger has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications and the pharmacokinetics, bioavailability, and the safety issues of ginger are discussed in this update.
Journal ArticleDOI
The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes.
Farzad Shidfar,Asadollah Rajab,Tayebeh Rahideh,Nafiseh Khandouzi,Sharieh Hosseini,Shahrzad Shidfar +5 more
TL;DR: Glycemic indices, total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), serum paraoxonase, dietary intake and physical activity were measured and showed that the differences between the ginger and placebo groups were statistically significant.