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Journal ArticleDOI

Glaucoma as a neurodegenerative disease.

Neeru Gupta, +1 more
- 01 Mar 2007 - 
- Vol. 18, Iss: 2, pp 110-114
TLDR
Glaucoma as a neurodegenerative disease is a valid working hypothesis to understand neural injury in the visual system and may stimulate the discovery of innovative intraocular pressure-independent strategies to help prevent loss of vision in glaucomA patients.
Abstract: 
Purpose of reviewGlaucoma is a leading cause of irreversible world vision loss characterized by progressive retinal ganglion cell death. Elevated eye pressure is a major risk factor for glaucoma; however, despite effective medical and surgical therapies to reduce intraocular pressure, progressive vi

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Citations
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Journal ArticleDOI

The retina as a window to the brain-from eye research to CNS disorders.

Anat London, +2 more
- 01 Jan 2013 - 
TL;DR: Data is summarized that support examination of the eyes as a noninvasive approach to the diagnosis of select CNS diseases, and the use of the eye as a valuable model to study the CNS.
Journal ArticleDOI

Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration

Ari J. Green, +4 more
- 01 Jun 2010 - 
TL;DR: This study provides the first large-scale pathological description of retinas in multiple sclerosis, including patients with different subtypes of disease at all stages, and with variable clinical severity.
Journal ArticleDOI

Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.

Victor T. T. Chan, +12 more
- 01 Apr 2019 - 
TL;DR: The results confirmed the associations between retinal measurements of SD OCT and AD, highlighting the potential usefulness ofSD OCT measurements as biomarkers of AD.
Journal ArticleDOI

Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging

Neeru Gupta, +5 more
- 01 Jan 2009 - 
TL;DR: In vivo MRI evidence of LGN degeneration in human glaucoma is consistent with ex vivo primate and human neuropathological studies, suggesting that LGN atrophy may be a relevant biomarker of visual system injury and/or progression in some glAUcoma patients.
Journal ArticleDOI

Oxidative and nitrative stress in neurodegeneration

Catherine Cobb, +1 more
- 01 Dec 2015 - 
TL;DR: A significant role is proposed for OS/NS and more specifically, lipid peroxidation (LPO) and other lipid modifications, by triggering microglial activation to elicit a neuroinflammatory state potentiated by diabetes or abnormal dopamine metabolism.
References
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Journal ArticleDOI

The number of people with glaucoma worldwide in 2010 and 2020

Harry A. Quigley, +1 more
- 01 Mar 2006 - 
TL;DR: Glaucoma is the second leading cause of blindness worldwide, disproportionately affecting women and Asians, and it will be 60.5 million people with OAG and ACG in 2010, increasing to 79.6 million by 2020, and of these, 74% will have OAG.
Journal ArticleDOI

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Michael T. Lin, +1 more
- 19 Oct 2006 - 
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
Journal ArticleDOI

Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial.

Anders Heijl, +5 more
- 01 Oct 2002 - 
TL;DR: The first adequately powered randomized trial with an untreated control arm to evaluate the effects of IOP reduction in patients with open-angle glaucoma who have elevated and normal IOP showed considerable beneficial effects of treatment that significantly delayed progression.
Journal ArticleDOI

The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deterioration

Fred Ederer, +7 more
- 01 Oct 2000 - 
TL;DR: In both analyses low intraocular pressure is associated with reduced progression of visual field defect, supporting evidence from earlier studies of a protective role for low intracular pressure in visual field deterioration.

Early manifest glaucoma trial group. reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial

Anders Heijl, +4 more
Related Papers (5)

The number of people with glaucoma worldwide in 2010 and 2020

Harry A. Quigley, +1 more
- 01 Mar 2006 - 

Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex

Neeru Gupta, +4 more
- 01 Jun 2006 - 

Primary open-angle glaucoma.

Robert N. Weinreb, +1 more
- 22 May 2004 - 

Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma.

Yeni H. Yücel, +5 more
- 01 Jul 2003 - 

Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis.

Yih Chung Tham, +5 more
- 01 Nov 2014 -