Showing papers in "Progress in Retinal and Eye Research in 2003"

TL;DR: Recent findings that VEGFs secreted by epithelia, including the retinal pigment epithelium (RPE), are likely to mediate paracrine vascular survival signals for adjacent endothelia may explain the pathogenesis of subretinal neovascularisation in AMD.

TL;DR: Retinal remodeling is not plasticity, but represents the invocation of mechanisms resembling developmental and CNS plasticities and together, neuronal remodeling and the formation of the glial seal may abrogate many cellular and bionic rescue strategies.

TL;DR: The time is right to apply the knowledge that has been gained regarding corneal endothelial cell proliferative capacity and regulation of its cell cycle to develop new therapies to treat patients at risk for vision loss due to low endothelial cells counts.

TL;DR: This review aims to build on existing models to illustrate that the prevention of aberrant scleral remodelling must be the goal of any long-term therapy for the amelioration of the permanent vision loss associated with high myopia.

TL;DR: It has been demonstrated that thioltransferase has a remarkable resistance to oxidation (H(2)O(2)) in cultured human and rabbit lens epithelial cells under oxidative stress conditions when other oxidation defense systems of GSH peroxidase and GSH reductase are severely inactivated.

TL;DR: In an experimental primate model of unilateral glaucoma, degenerative changes are observed in magnocellular, parvo cellular, and koniocellular pathways in the lateral geniculate nucleus, and these changes are presented in relation to intraocular pressure and the severity of optic nerve damage.

TL;DR: The mfVEP does have a place in the clinical management of glaucoma, although it is not likely to replace or augment static automated achromatic perimetry, and the relative advantages of the HVF and the m fVEP are summarized.

TL;DR: Several anti-angiogenic approaches are being developed in animal models to prevent ocular angiogenesis by blocking the key steps of the angiogenic cascade.

TL;DR: Exfoliation syndrome is an age-related, generalized disorder of the extracellular matrix characterized by production and progressive accumulation of a fibrillar material in tissues throughout the anterior segment and also in connective tissue portions of various visceral organs.

TL;DR: Evidence for a carbonic anhydrase mediated CO(2)-diffusive mode of apical HCO(3)(-) flux is incorporated into a new model of transendothelial anion transport, which suggests that there are a number of alternate pathways for anions transport.

TL;DR: The specific roles of cell-matrix and cell-cell interactions during the course of corneal epithelial wound healing are described and the clinical implications of the basic research findings are discussed.

TL;DR: It is hoped that the near future will bring effective therapies for many retinal dystrophy patients with defects in vitamin A metabolism, including retinoid and gene replacement therapy.

TL;DR: The molecular determinants of RGC fate determination and the development of the retino-tectal projection are reviewed and perspectives towards neuroprotection and regeneration of adult lesioned RGCs that may be applicable to lesioned CNS neurons in vertebrates in a broader sense are developed.

TL;DR: A summary of the current understanding of rhodopsin phosphorylation and the properties of r Rhodopsin kinase is presented, along with some expectations of future investigations into these topics.

TL;DR: This overview presents the current knowledge of the mechanical properties of the human lens capsule on basis of its structure and its role in accommodation and cataract surgery.

TL;DR: It is intimate that few antiglaucoma medications have the potential to directly improve ocular blood flow, and longitudinal, prospective, randomized trials are needed to investigate the effects of vasoactive substances with no hypotensive effect on the progression of glaucomA.

TL;DR: This paper provides a review of both the experimental and theoretical progress, and summarizes the results of fundamental and clinical research using fundus reflectometry.

TL;DR: An overview of recent advances in the understanding of the cellular and molecular mechanisms underlying retinal neuronal diversification, with a particular focus on cell-intrinsic factors is provided.

TL;DR: In this article, the in vivo confocal findings of common refractive procedures and their complications are described, and their biology is discussed in light of the existing knowledge on wound healing phenomena.

TL;DR: A framework for study of retinal vascular development is provided, the common use of perinatal retinal models in angiogenesis research is validated, and the cellular basis of retinopathy of prematurity is clarified.

TL;DR: It is demonstrated that the retina is an insulin-sensitive tissue, and the hypothesis that dysfunctional insulin receptor signaling in the retina contributes to cell dysfunction and death in retinal diseases is addressed.

TL;DR: The ability of the trabecular meshwork tissue to respond to mechanical and biochemical insults is possibly driven by induction or repression of a number of genes that, most likely, are different from those involved in regulation of normal IOP.

TL;DR: This work suggests that adenosine and its receptors may be a therapeutic target in OIR, and is supported by recent studies in mouse which demonstrated that targeting one of the A(2) receptors can inhibit formation of neovascularization in O IR.

TL;DR: The techniques and applications for isolated ocular vascular preparations and their significance to ophthalmic research are outlined to highlight the relevance of such studies to the understanding of the pathogenesis of eye diseases involving the vasculature.

TL;DR: Data obtained with cone and rod specific stimuli may lead to a reinterpretation of the standard ERG used in a clinical setting and help to develop better diagnostic tools and result in a fuller description of the changes and the pathophysiological mechanisms in retinal disorder.

TL;DR: The functional role of C-type horizontal cells is to influence the spatial-chromatic organization of the receptive fields of proximal neurons, and the responsiveness of bipolar cells and ganglion cells to surround illumination depend to a great extent upon the horizontal cells.

TL;DR: An overview of the properties of AAV vectors is provided followed by a detailed report of their use in retinal gene transfer for mendelian and non-mendelian disorders.

TL;DR: It is shown that even antibodies recognizing the same antigen in both serum and IOF still differ in the epitopes they recognize, which reveals that the intraocular compartment largely determines its own antibody profile in the defence against intra-ocular pathogens.

TL;DR: This chapter focuses attention on the most promising candidate genes for gene therapy in ocular immune diseases, and outlines the current techniques for delivering genes of interest with their potential merits and drawbacks in the field of ophthalmology.

TL;DR: The corrected version of Table 1 on p. 172 is now reproduced on the following page as mentioned in this paper, along with the corrected version on page 173 right-hand column, three lines from the bottom of the page occurred: triglycerides should read triacylglycerides.