Global burden of human papillomavirus and related diseases.

TLDR: Cervical cancer is the third most common female malignancy and shows a strong association with level of development, rates being at least four-fold higher in countries defined within the low ranking of the Human Development Index (HDI) compared with those in the very high category.

About: This article is published in Vaccine.The article was published on 2012-11-20 and is currently open access. It has received 1342 citations till now. The article focuses on the topics: HPV infection & Genital warts.

Figures

Table 5 Worldwide burden of cervical cancer, GLOBOCAN 2008 estimatesa by level of Human Development Index (HDI)b.

Figure 1. HPV prevalence among women with normal cytology: meta-analysis based on results from 1,016,719 women. aRegionally-adjusted HPV (see [1] for adjustment methodology). Redrawn from Bruni L et al. [1].

Table 1 Results from meta-analysis showing number of women tested for HPV and HPV16, number and percent positive by cervical disease grade.

Table 4 shows a more detailed breakdown of attributable cases by cancer site, cross-tabulated by sex, age group and development status. Cervical cancer accounted for most of the attributable cases (86.9%) with the other five cancer types accounting for the residual 80,000 cancers. Younger women showed a high burden of HPVrelated cancer, with almost half the cases occurring before the age of 50 years.

Table 2 Methods for the calculation of the Population Attributable Fraction associated with HPV by cancer site.

Figure 11. Cancers, other than cervix uteri, associated with HPV infection, age-standardiz selected cancer registry populations (all ages). Based on Cancer Incidence in Five Contine Program [25]. Data are for males (M) and females (F) combined for orpharynx and anus; o (world standard) rate.

Frequently asked questions

Q1. What contributions have the authors mentioned in the paper "Global burden of human papillomavirus and related diseases" ?

Estimates of the projected incidence of cervical cancer in 2030, based solely on demographic factors, indicate a 2 % increase in the global burden of cervical cancer, i. e., in balance with the current rate of decline. This article forms part of a special supplement entitled “ Comprehensive Control of HPV Infections and Volu Related Diseases ” Vaccine