Journal ArticleDOI
Gluconeogenesis and Related Aspects of Glycolysis
Henri-Géry Hers,Louis Hue +1 more
TLDR
The control of metABOLIC FLUX by HORMONES and other EFFECTORS and the development of novel approaches to this problem are described.Citations
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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.
TL;DR: It is proposed that type I Ptdlns kinase is responsible for the generation of PtdIns(3)P in intact cells, and that this novel phosphoinositide could be important in the transduction of mitogenic and oncogenic signals.
Journal ArticleDOI
A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks.
TL;DR: This work analyzes the interplay between the pentose phosphate pathway (PPP) and glycolysis to define and comprehensively describe all metabolic routes that are both stoichiometrically and thermodynamically feasible for a group of enzymes.
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Metabolic rate depression and biochemical adaptation in anaerobiosis, hibernation and estivation
TL;DR: The present review focuses on the molecular control mechanisms that regulate and coordinate cellular metabolism for the transition into dormancy, which form a common molecular basis for metabolic depression in anoxia-tolerant vertebrates and invertebrates, hibernation in small mammals, and estivation in land snails and terrestrial toads.
Journal ArticleDOI
On elementary flux modes in biochemical reaction systems at steady state
TL;DR: It is shown that for systems in which all flux- have fixed signs, all elementary modes are given by the generating vectors of a convex cone and can, thus, be computed by an existing algorithm.
Journal ArticleDOI
The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism.
TL;DR: The methods by which the intra-mitochondrial volume is measured both in vitro and in situ are described, the mechanisms thought to regulate the mitochondrial volume are summarised and evidence that changes in mitochondrial volume may be important in the responses of a variety of tissues to hormones and other stimuli is provided.
References
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Book
Gluconeogenesis, its regulation in mammalian species
TL;DR: This book exhaustively review the regulation of gluconeogenesis in different animal species and includes an excellent discussion of the regulatory role of mitochondria1 anion transport by John Williamson, which embraces the broader aspects of metabolic regulation.