Open AccessJournal Article
Glucose-6-phosphate dehydrogenase deficiency.
I Siswadi,H Notopuro,S Untario +2 more
TLDR
A defect in an enzyme called glucose-6-phosphate dehydrogenase causes red blood cells to break down prematurely, which results in the destruction ofRed blood cells, which carry oxygen from the lungs to tissues throughout the body.Abstract:
Glucose-6-phosphate dehydrogenase deficiency is a genetic disorder that occurs almost exclusively in males. This condition mainly affects red blood cells, which carry oxygen from the lungs to tissues throughout the body. In affected individuals, a defect in an enzyme called glucose-6-phosphate dehydrogenase causes red blood cells to break down prematurely. This destruction of red blood cells is called hemolysis.read more
Citations
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Journal ArticleDOI
Glucose-6-phosphate dehydrogenase deficiency
Cappellini,Gemino Fiorelli +1 more
TL;DR: The most effective management of G6PD deficiency is to prevent haemolysis by avoiding oxidative stress, and Screening programmes for the disorder are undertaken, depending on the prevalence of G 6PD deficiency in a particular community.
Journal ArticleDOI
On the allelic spectrum of human disease.
David Reich,Eric S. Lander +1 more
TL;DR: Human disease genes show enormous variation in their allelic spectra; that is, in the number and population frequency of the disease-predisposing alleles at the loci, so the theory does a reasonable job for diseases where the genetic etiology is well understood.
Journal ArticleDOI
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Anna Stincone,Alessandro Prigione,Thorsten Cramer,Mirjam M.C. Wamelink,Kate Campbell,Eric Cheung,Viridiana Olin-Sandoval,Nana-Maria Grüning,Antje Krüger,Mohammad Tauqeer Alam,Markus A. Keller,Michael Breitenbach,Kevin M. Brindle,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser +15 more
TL;DR: The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism as discussed by the authors, which shares reactions with the Entner-Doudoroff pathway and the Calvin cycle and divides into an oxidative and non-oxidative branch.
Book
Disease and Mortality in Sub-Saharan Africa
TL;DR: In this paper, the authors present a review of health policy in sub-Saharan Africa focusing on the key elements of immunization and oral rehydration, and discuss the potential value of explicitly seeking lessons from the Bank's experience with health sector operations in Africa.
Journal ArticleDOI
The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis.
TL;DR: The magnitude and variation in global, regional, and country-level prevalence rates of G6PD deficiency are of public health import, particularly in planning programs to improve neonatal health and in the distribution of various medications, especially antimalarial drugs, as G6 PD deficiency is most prevalent in malaria-endemic areas.
References
More filters
Journal ArticleDOI
Glucose-6-phosphate dehydrogenase deficiency
Cappellini,Gemino Fiorelli +1 more
TL;DR: The most effective management of G6PD deficiency is to prevent haemolysis by avoiding oxidative stress, and Screening programmes for the disorder are undertaken, depending on the prevalence of G 6PD deficiency in a particular community.
Journal ArticleDOI
On the allelic spectrum of human disease.
David Reich,Eric S. Lander +1 more
TL;DR: Human disease genes show enormous variation in their allelic spectra; that is, in the number and population frequency of the disease-predisposing alleles at the loci, so the theory does a reasonable job for diseases where the genetic etiology is well understood.
Journal ArticleDOI
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Anna Stincone,Alessandro Prigione,Thorsten Cramer,Mirjam M.C. Wamelink,Kate Campbell,Eric Cheung,Viridiana Olin-Sandoval,Nana-Maria Grüning,Antje Krüger,Mohammad Tauqeer Alam,Markus A. Keller,Michael Breitenbach,Kevin M. Brindle,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser +15 more
TL;DR: The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism as discussed by the authors, which shares reactions with the Entner-Doudoroff pathway and the Calvin cycle and divides into an oxidative and non-oxidative branch.
Book
Disease and Mortality in Sub-Saharan Africa
TL;DR: In this paper, the authors present a review of health policy in sub-Saharan Africa focusing on the key elements of immunization and oral rehydration, and discuss the potential value of explicitly seeking lessons from the Bank's experience with health sector operations in Africa.
Journal ArticleDOI
The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis.
TL;DR: The magnitude and variation in global, regional, and country-level prevalence rates of G6PD deficiency are of public health import, particularly in planning programs to improve neonatal health and in the distribution of various medications, especially antimalarial drugs, as G6 PD deficiency is most prevalent in malaria-endemic areas.