Glutathione: new roles in redox signaling for an old antioxidant
TLDR
This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.Abstract:
The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.read more
Citations
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Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
TL;DR: A better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.
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The role of glutathione reductase and related enzymes on cellular redox homoeostasis network.
TL;DR: The role of glutathione reductase in the regulation, modulation and maintenance of cellular redox homoeostasis, and therapeutic targets to overcome oxidative stress associated cellular disorders are evaluated.
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NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism
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Targeting ferroptosis as a vulnerability in cancer
Guang Lei,Li Zhuang,Boyi Gan +2 more
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Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update
TL;DR: This new direction in improving antioxidant defences for poultry in stress conditions is related to an opportunity to activate a range of vitagenes via Nrf2-related mechanisms to maximise internal AO protection and redox balance maintenance.
References
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