Journal ArticleDOI
Glycosaminoglycan entrapment by fibrin in engineered heart valve tissues.
Abraham Alfonso,Sasmita Rath,Parvin Rafiee,Mario Hernandez-Espino,Mahreen Din,Florence George,Sharan Ramaswamy +6 more
Reads0
Chats0
TLDR
It is concluded that fibrin in the flex-flow culture of engineered heart valve tissues augments PLC-derived collagen production; and enhances retention of GAGs within the developing ECM.About:
This article is published in Acta Biomaterialia.The article was published on 2013-09-01. It has received 15 citations till now. The article focuses on the topics: Fibrin & Extracellular matrix.read more
Citations
More filters
Journal ArticleDOI
Current progress in tissue engineering of heart valves: multiscale problems, multiscale solutions
TL;DR: This review will cover current tissue engineering strategies in fabricating heart valves and their progress towards the clinic, including molded scaffolds using naturally derived or synthetic polymers, decellularization, electrospinning, 3D bioprinting, hybrid techniques, and in vivo engineering.
Current progress in tissue engineering of heart valves: multiscale problems, multiscale
TL;DR: In this paper, a review of tissue engineering strategies in fabricating living heart valves and their progress towards the clinic is presented, including molded scaffolds using naturally derived or synthetic polymers, decellularization, electrospinning, 3D bioprinting, hybrid techniques and in vivo engineering.
Journal ArticleDOI
Incorporation of fibrin into a collagen-glycosaminoglycan matrix results in a scaffold with improved mechanical properties and enhanced capacity to resist cell-mediated contraction.
Claire Brougham,Tanya J. Levingstone,Stefan Jockenhoevel,Thomas C. Flanagan,Fergal J. O'Brien,Fergal J. O'Brien +5 more
TL;DR: This is the first scaffold manufactured from all naturally derived materials that resists cell-mediated contraction, and shows potential for use in applications where dimensional stability is crucial to the functionality of the tissue.
Journal ArticleDOI
Bioengineered living cardiac and venous valve replacements: current status and future prospects
TL;DR: Basic principals and current scientific status of valvular tissue engineering are reviewed, including a critical discussion and outlook for the future.
Journal ArticleDOI
Differentiation and Distribution of Marrow Stem Cells in Flex-Flow Environments Demonstrate Support of the Valvular Phenotype
TL;DR: Results indicate that flex-flow mechanical environments support directed in vitro differentiation of BMSCs uniquely towards a heart valve phenotype, as evident by cellular distribution and expression of specific gene markers.
References
More filters
Journal ArticleDOI
Functional Living Trileaflet Heart Valves Grown In Vitro
Simon P. Hoerstrup,Ralf Sodian,Sabine Daebritz,Jun Wang,Emile A. Bacha,David P. Martin,Adrian M. Moran,Kristine J. Guleserian,Jason S. Sperling,Sunjay Kaushal,Joseph P. Vacanti,Frederick J. Schoen,John E. Mayer +12 more
TL;DR: In vitro generation of implantable complete living heart valves based on a biomimetic flow culture system that functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation.
Journal ArticleDOI
Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering
Qing Ye,Gregor Zünd,Peter Benedikt,Stefan Jockenhoevel,Simon P. Hoerstrup,Shelly Sakyama,Jeffrey A. Hubbell,Marko Turina +7 more
TL;DR: A three-dimensional fibrin gel structure can serve as a useful scaffold for tissue engineering with controlled degradation, excellent seeding effects and good tissue development.
Journal ArticleDOI
Fibrin gel -- advantages of a new scaffold in cardiovascular tissue engineering.
Stefan Jockenhoevel,Gregor Zünd,Simon P. Hoerstrup,K. Chalabi,Jörg S. Sachweh,L. Demircan,Bruno J. Messmer,Marko Turina +7 more
TL;DR: Fibrin gel combines a number of important properties of an ideal scaffold and can be produced as a complete autologous scaffold that is moldable and degradation is controllable by the use of aprotinin.
Journal ArticleDOI
Heart valve function: a biomechanical perspective
TL;DR: The present review focuses on the functional biomechanics of HVs, and refers to the unique aspects of valvular function, and how the mechanical and mechanobiological behaviours of the constituent biological materials achieve this remarkable feat.
Journal ArticleDOI
From Stem Cells to Viable Autologous Semilunar Heart Valve
Fraser W.H Sutherland,Fraser W.H Sutherland,Tjorvi E. Perry,Ying Yu,Megan C. Sherwood,Elena Rabkin,Yutaka Masuda,G. Alejandra Garcia,Dawn L. McLellan,George C. Engelmayr,Michael S. Sacks,Frederick J. Schoen,John E. Mayer +12 more
TL;DR: Stem-cell tissue-engineered heart valves can be created from mesenchymal stem cells in combination with a biodegradable scaffold and function satisfactorily in vivo for periods of >4 months, and undergo extensive remodeling in vivo to resemble native heart valves.