Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis
Chuanfa Ni,Mingyou Hu,Jinbo Hu +2 more
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This article is published in Chemical Reviews.The article was published on 2015-01-28 and is currently open access. It has received 873 citations till now. The article focuses on the topics: Organic synthesis & Sulfur.read more
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Iridium-Catalyzed Asymmetric Allylic Substitution Reactions
TL;DR: In this review, an explicit outline of ligands, mechanism, scope of nucleophiles, and applications is presented, including ligand development, mechanistic understanding, substrate scope, and application in the synthesis of complex functional molecules.
Journal ArticleDOI
The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations
Chuanfa Ni,Jinbo Hu +1 more
TL;DR: This tutorial review provides a brief overview of the unique fluorine effects in recently developed nucleophilic, electrophilic, radical, and transition metal-mediated fluoroalkylation reactions by comparing with either their non-fluorinated counterparts or fluorinated counterparts with different numbers of fluorine substituents.
Journal ArticleDOI
Bond-Forming and -Breaking Reactions at Sulfur(IV): Sulfoxides, Sulfonium Salts, Sulfur Ylides, and Sulfinate Salts.
TL;DR: This review aims to cover the developments of the past decade in the chemistry of organic sulfur(IV) molecules and provide insight into both the wide range of reactions which critically rely on this versatile element and the diverse scaffolds that can thereby be synthesized.
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Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs
Yi Zhu,Jianlin Han,Jiandong Wang,Norio Shibata,Mikiko Sodeoka,Vadim A. Soloshonok,Vadim A. Soloshonok,Jaime A. S. Coelho,F. Dean Toste +8 more
TL;DR: A comprehensive review of current research activity in asymmetric construction of quaternary C-F stereogenic centers is provided, including such general directions as asymmetric electrophilic fluorination via organocatalytic and transition-metal catalyzed reactions, asymmetric elaboration of fluorine-containing substrates via alkylations, Mannich, Michael, and aldol additions, cross-coupling reactions, and bioc atalytic approaches.
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Fine Design of Photoredox Systems for Catalytic Fluoromethylation of Carbon–Carbon Multiple Bonds
Takashi Koike,Munetaka Akita +1 more
TL;DR: This Account focuses on recent research on photoredox-catalyzed fluoromethylation of carbon-carbon multiple bonds in organofluorine compounds bearing C(sp(3))-CF3 bonds and choices of the photocatalyst and the fluorometrichylating reagent are explained.
References
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Fluorine in Pharmaceuticals: Looking Beyond Intuition.
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
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Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).
Jiang Wang,María Sánchez-Roselló,José Luis Aceña,Carlos del Pozo,Alexander E. Sorochinsky,Alexander E. Sorochinsky,Alexander E. Sorochinsky,Santos Fustero,Vadim A. Soloshonok,Vadim A. Soloshonok,Hong Liu +10 more
TL;DR: Introduced to the Market in the Last Decade (2001−2011) Jiang Wang,† María Sańchez-Rosello,́‡,§ Jose ́ Luis Aceña, Carlos del Pozo,‡ and Hong Liu.
Book
Substituent constants for correlation analysis in chemistry and biology
Corwin Hansch,Albert J. Leo +1 more
TL;DR: In this paper, the book is the window to get in the world and you can open the world easily, and these wise words are really familiar with you, so bring home now the book enPDFd substituent constants for correlation analysis in chemistry and biology to be your sources when going to read.
Journal ArticleDOI
Catalysis for fluorination and trifluoromethylation
TL;DR: Reactions to make organofluorides that have emerged within the past few years are discussed and which exemplify how to overcome some of the intricate challenges associated with fluorination.