Growth Differentiation Factor-15 and Risk of Recurrent Events in Patients Stabilized After Acute Coronary Syndrome: Observations From PROVE IT-TIMI 22
Marc P. Bonaca,David A. Morrow,Eugene Braunwald,Christopher P. Cannon,Songtao Jiang,Stephanie Breher,Marc S. Sabatine,Tibor Kempf,Lars Wallentin,Kai C. Wollert +9 more
TLDR
GDF-15 is associated with recurrent events after ACS, independent of clinical predictors, B-type natriuretic peptide, and high-sensitivity C-reactive protein, and this finding supports GDF- 15 as a prognostic marker in ACS and investigation of other therapies that modify this risk.Abstract:
Objective— To investigate growth differentiation factor (GDF)-15 at hospital discharge for assessment of the risk of death, recurrent myocardial infarction (MI), and congestive heart failure, and to determination of whether these risks can be modified by statins. Methods and Results— GDF-15 is a transforming growth factor-β–related cytokine induced in response to tissue injury. GDF-15 concentration is associated with all-cause mortality in patients with acute coronary syndrome (ACS). We measured GDF-15 in 3501 patients after ACS, treated with moderate or intensive statin therapy in PROVE IT-TIMI 22. By using established cutoff points, GDF-15 ( 1800 ng/L) was associated with 2-year risk of death or MI (5.7%, 8.1%, and 15.1%, respectively; P P P P P P P P P =0.24 for the interaction). Conclusion— GDF-15 is associated with recurrent events after ACS, independent of clinical predictors, B-type natriuretic peptide, and high-sensitivity C-reactive protein. This finding supports GDF-15 as a prognostic marker in ACS and investigation of other therapies that modify this risk.read more
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GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
Tibor Kempf,Alexander Zarbock,Christian Widera,Stefan Butz,Anika Stadtmann,Jan Rossaint,Matteo Bolomini-Vittori,Mortimer Korf-Klingebiel,L. Christian Napp,Birte Hansen,Anna Kanwischer,Udo Bavendiek,Gernot Beutel,Martin Hapke,Martin Sauer,Carlo Laudanna,Nancy Hogg,Dietmar Vestweber,Kai C. Wollert +18 more
TL;DR: GDF-15 is the first cytokine identified as an inhibitor of PMN recruitment by direct interference with chemokine signaling and integrin activation, and loss of this anti-inflammatory mechanism leads to fatal cardiac rupture after myocardial infarction.
Journal ArticleDOI
Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease.
TL;DR: GDF-15 captures distinct aspects of CV disease development, progression, and prognosis, which are not represented by clinical risk predictors and other biomarkers, and may become useful for decision support.
Journal ArticleDOI
GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective
Ramu Adela,Sanjay K. Banerjee +1 more
TL;DR: It is a challenge for the scientific community to use GDF-15 information for patient monitoring, clinical decision-making, and replacement of current treatment strategies for diabetic and cardiovascular diseases.
Journal ArticleDOI
Growth Differentiation Factor 15, a Marker of Oxidative Stress and Inflammation, for Risk Assessment in Patients With Atrial Fibrillation Insights From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial
Lars Wallentin,Ziad Hijazi,Ulrika Andersson,John H. Alexander,Raffaele De Caterina,Michael G. Hanna,John D. Horowitz,Elaine M. Hylek,Renato D. Lopes,Signild Åsberg,Christopher B. Granger,Agneta Siegbahn +11 more
TL;DR: Apixaban consistently reduced stroke, mortality, and bleeding, regardless of GDF-15 levels, and the prognostic value for major bleeding and death remained even in the presence of N-terminal pro-brain natriuretic peptide and high-sensitivity troponin I.
Journal ArticleDOI
The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism.
Samuel N. Breit,Heiko Johnen,Andrew D. Cook,Vicky Wang-Wei Tsai,Mohammad G. Mohammad,Tamara Kuffner,Hong Ping Zhang,Christopher P. Marquis,Lele Jiang,Glen P. Lockwood,Michelle Lee-Ng,Yasmin Husaini,Liyun Wu,John A. Hamilton,David Brown +14 more
TL;DR: Available data suggest MIC-1/GDF15 may be an important molecule mediating the interplay between cancer, obesity and chronic inflammation, suggesting a fundamental role in biological processes associated with ageing.
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