Journal ArticleDOI
Guidelines for the management of acute cervical spine and spinal cord injuries: 2013 update.
Beverly C. Walters,Mark N. Hadley,R. John Hurlbert,Bizhan Aarabi,Sanjay S. Dhall,Daniel E. Gelb,Mark R. Harrigan,Curtis J. Rozelle,Timothy C. Ryken,Nicholas Theodore +9 more
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TLDR
The purpose of this article is to provide an overview of the changes in the recommendations as a result of new evidence or broadened scope.Abstract:
In 2002, an author group selected and sponsored by the Joint Section on Spine and Peripheral Nerves of the American Association of Neurological Surgeons and Congress of Neurological Surgeons published the first evidence-based guidelines for the management of patients with acute cervical spinal cord injuries (SCIs). In the spirit of keeping up with changes in information available in the medical literature that might provide more contemporary and more robust medical evidence, another author group was recruited to revise and update the guidelines. The review process has been completed and is published and can be once again found as a supplement to Neurosurgery. The purpose of this article is to provide an overview of the changes in the recommendations as a result of new evidence or broadened scope.read more
Citations
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Journal ArticleDOI
Traumatic Spinal Cord Injury.
TL;DR: The treatment of traumatic spinal cord injury remains supportive, and prognosis is still poor for patients who are severely affected, and future efforts would be most useful if focused on injury prevention and the development of effective neuroregenerative therapies.
Journal ArticleDOI
Review of treatment trials in human spinal cord injury: issues, difficulties, and recommendations.
TL;DR: A large number of trials in the field of spinal cord injury have been conducted, but with few proven gains for patients, and this review reveals several shortcomings in trial design and makes several recommendations for improvement.
Book ChapterDOI
The clinical problems in cardiovascular control following spinal cord injury: an overview.
TL;DR: This chapter will focus on the clinical issues related to abnormal cardiovascular control in individuals with spinal cord injury, which include neurogenic shock, autonomic dysreflexia and orthostatic hypotension.
Journal ArticleDOI
A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury
Michael G. Fehlings,Nicholas Theodore,James S. Harrop,Gilles Maurais,Charles Kuntz,Christopher I. Shaffrey,Brian K. Kwon,Jens R. Chapman,Albert Yee,Allyson Tighe,Lisa McKerracher +10 more
TL;DR: The observed motor recovery in this open-label trial suggests that BA-210 may increase neurological recovery after complete SCI, and further clinical trials with Cethrin in SCI patients are planned, to establish evidence of efficacy.
Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004
Todd J. Albert,David H. Kim +1 more
TL;DR: In this paper, the authors suggest that the early post-injury period may present a unique opportunity for meaningful intervention, based on results obtained in animal studies that demonstrate the potential for improving functional outcome when surgical intervention is performed within a few hours following experimental spinal cord injury.
References
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Journal ArticleDOI
A critical appraisal of the reporting of the National Acute Spinal Cord Injury Studies (II and III) of methylprednisolone in acute spinal cord injury.
William P. Coleman,Edward C. Benzel,David W. Cahill,Thomas B. Ducker,Fred H. Geisler,Barth A. Green,Mitchell R. Gropper,Jan Goffin,Parley W. Madsen,Dennis J. Maiman,Stephen L. Ondra,Michael K. Rosner,Rick C. Sasso,Gregory R. Trost,Seth M. Zeidman +14 more
TL;DR: The NASCIS group's decision to admit persons with minor SCIs with minimal or no motor deficit not only enables statistical artifacts it complicates the interpretation of results from the population actually sampled, and the results of these studies show statistical artifacts that call their results into question.
Journal ArticleDOI
A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury
Michael G. Fehlings,Nicholas Theodore,James S. Harrop,Gilles Maurais,Charles Kuntz,Christopher I. Shaffrey,Brian K. Kwon,Jens R. Chapman,Albert Yee,Allyson Tighe,Lisa McKerracher +10 more
TL;DR: The observed motor recovery in this open-label trial suggests that BA-210 may increase neurological recovery after complete SCI, and further clinical trials with Cethrin in SCI patients are planned, to establish evidence of efficacy.
Journal ArticleDOI
Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells.
Masaya Nakamura,Hideyuki Okano +1 more
TL;DR: The pre-clinical investigations of cell therapy for spinal cord injury (SCI) using neural stem/progenitor cells derived from iPS cells, and their safety issues in vivo are outlined and the strategy for the first human trails of iPS cell-based cell Therapy for SCI patients is discussed.
Journal ArticleDOI
Pharmacological therapy after acute cervical spinal cord injury.
Mark N. Hadley,Beverly C. Walters,Paul A. Grabb,Nelson M. Oyesiku,G J Przybylski,Daniel K. Resnick,Timothy C. Ryken +6 more
TL;DR: Treatment of patients with acute spinal cord injuries with GM-1 ganglioside is recommended as an option without demonstrated clinical benefit, and treatment with methylprednisolone for either 24 or 48 hours is recommended.
Journal ArticleDOI
Blood pressure management after acute spinal cord injury.
Mark N. Hadley,Beverly C. Walters,Paul A. Grabb,Nelson M. Oyesiku,G J Przybylski,Daniel K. Resnick,Timothy C. Ryken +6 more
TL;DR: Maintenance of mean arterial blood pressure at 85 to 90 mmHg for the first 7 days after acute spinal cord injury to improve spinal cord perfusion is recommended.
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