Howard Lesiuk

TL;DR: The Canadian CT Head Rule is developed, a highly sensitive clinical decision rule for use of CT that has the potential to significantly standardise and improve the emergency management of patients with minor head injury.

TL;DR: The Canadian C-Spine Rule is derived, a highly sensitive decision rule that will allow emergency department (ED) physicians to be more selective in use of radiography in alert and stable trauma patients and has the potential to significantly reduce practice variation and inefficiency in ED use of C-spine radiography.

TL;DR: For alert patients with trauma who are in stable condition, the CCR is superior to the NLC with respect to sensitivity and specificity for cervical-spine injury, and its use would result in reduced rates of radiography.

TL;DR: For patients with minor head injury and GCS score of 15, the Canadian CT Head Rule and the NOC have equivalent high sensitivities for need for neurosurgical intervention and clinically important brain injury, but the CCHR has higher specificity for important clinical outcomes than does the N OC, and its use may result in reduced imaging rates.

TL;DR: Nerinetide did not improve the proportion of patients achieving good clinical outcomes after endovascular thrombectomy compared with patients receiving placebo, and this trial is registered with ClinicalTrials.gov, NCT02930018.