Health Risk Assessment of Dietary Cadmium Intake: Do Current Guidelines Indicate How Much is Safe?
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TLDR
Modeling shows that dietary intake levels for Cd exceed the levels associated with kidney damage and many other adverse outcomes, and the threshold level of urinary Cd should be re-evaluated.Abstract:
Background:Cadmium (Cd), a food-chain contaminant, is a significant health hazard. The kidney is one of the primary sites of injury after chronic Cd exposure. Kidney-based risk assessment establish...read more
Citations
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Journal ArticleDOI
The Effects of Cadmium Toxicity
Giuseppe Genchi,Maria Stefania Sinicropi,Graziantonio Lauria,Alessia Carocci,Alessia Catalano +4 more
TL;DR: Recent studies show that cadmium induces various epigenetic changes in mammalian cells, both in vivo and in vitro, causing pathogenic risks and the development of various types of cancers.
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Environmental pollution and kidney diseases
TL;DR: In this paper, the authors highlight epidemiological evidence for the association between kidney disease and environmental pollutants, including air pollution, heavy metal pollution and other environmental risk factors, and discuss the potential biological mechanisms that link exposure to environmental pollutants to kidney damage.
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Biochars induced modification of dissolved organic matter (DOM) in soil and its impact on mobility and bioaccumulation of arsenic and cadmium.
Gang Li,Sardar Khan,Sardar Khan,Muhammad Ibrahim,Tian Ran Sun,Jian Feng Tang,James B. Cotner,Yaoyang Xu +7 more
TL;DR: The results highlight the potential of biochar-DOM interactions as an important mechanism for suppressing the mobility and bioaccumulation of As and Cd in bio char-amended paddy agricultural systems.
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Dietary cadmium intake and its effects on kidneys
TL;DR: Measurements of Cd intake levels and its effects on kidneys have traditionally been made underpin the derivation of the current toxicity threshold limit and tolerable intake levels for Cd.
Journal ArticleDOI
Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies
TL;DR: More attention is drawn to Cd as an environmental risk factor for the health of the general population and the need to undertake preventive actions allowing to reduce the risk of health damage due to a lifetime exposure to this toxic metal.
References
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Journal ArticleDOI
A kinetic model of cadmium metabolism in the human being
TL;DR: The model was used to calculate the daily cadmium intake necessary to reach critical concentration in kidney cortex, and the average renal cortex concentration would reach 200 μg/g at an average daily cad mium intake via food of 440 μg for a European-American population and 325 μg for the Japanese population.
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Dietary exposure to trace elements and health risk assessment in the 2nd French Total Diet Study.
Nathalie Arnich,Véronique Sirot,Gilles Rivière,Julien Jean,Laurent Noël,Thierry Guérin,Jean-Charles Leblanc +6 more
TL;DR: Dietary exposure of the French population to trace elements has been assessed in the second national Total Diet Study and the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) reiterates its recommendation for a diversified diet.
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Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general population.
Maria Tellez-Plaza,Ana Navas-Acien,Andy Menke,Ciprian M. Crainiceanu,Roberto Pastor-Barriuso,Eliseo Guallar +5 more
TL;DR: Evidence is found that cadmium, at substantially low levels of exposure, remains an important determinant of all-cause and CVD mortality in a representative sample of U.S. adults and efforts to further reduce Cadmium exposure in the population could contribute to a substantial decrease in CVD disease burden.