Journal ArticleDOI
Hemin-induced lipid membrane disorder and increased permeability: a molecular model for the mechanism of cell lysis.
TLDR
The present results provide a molecular model for an alternative mechanism of lysis that would dominate in cases where the concentration is high enough for hemin to aggregate and aggregates are responsible for the enhancement of permeability and membrane disorder.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1993-11-01. It has received 210 citations till now. The article focuses on the topics: Membrane permeability & Hemin.read more
Citations
More filters
Journal ArticleDOI
Free heme toxicity and its detoxification systems in human
Sanjay Kumar,Uday Bandyopadhyay +1 more
TL;DR: Free heme acts as a pro-inflammatory molecule and heme-induced inflammation is involved in the pathology of diverse conditions; such as renal failure, arteriosclerosis, and complications after artificial blood transfusion, peritoneal endometriosis, and heart transplant failure.
Journal ArticleDOI
Characterization of heme as activator of Toll-like receptor 4.
Rodrigo T. Figueiredo,Patricia L. Fernández,Diego Mourão-Sá,Bárbara N. Porto,Fabianno F. Dutra,Letícia S. Alves,Marcus F. Oliveira,Pedro L. Oliveira,Aurélio V. Graça-Souza,Marcelo T. Bozza +9 more
TL;DR: It is demonstrated that heme, but not its analogs/precursors, induced tumor necrosis factor-α (TNF-α) secretion by macrophages dependently on MyD88, TLR4, and CD14, and these findings support the concept that the broad ligand specificity ofTLR4 and the different activation profiles might in part reside in its ability to recognize different ligands in different binding sites.
Journal ArticleDOI
Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action.
TL;DR: It is found that CQ and amodiaquine competitively inhibit the degradation of heme by glutathione, thus allowing heme to accumulate in membranes, and a relationship exists between membrane heme levels and the extent of parasite killing.
Journal ArticleDOI
Adaptations against heme toxicity in blood-feeding arthropods
Aurélio V. Graça-Souza,Clarissa M. Maya-Monteiro,Gabriela O. Paiva-Silva,Glória R.C. Braz,Marcia Cristina Paes,Marcos Henrique Ferreira Sorgine,Marcus F. Oliveira,Pedro L. Oliveira +7 more
TL;DR: In this paper, the authors review mechanisms by which heme can exert biological damage, together with a wide spectrum of adaptations developed by blood-feeding insects and ticks to counteract its deleterious effects.
Minireview Adaptations against heme toxicity in blood-feeding arthropods
Clarissa M. Maya-Monteiro,Gabriela O. Paiva-Silva,C. Paes,Marcus F. Oliveira,Pedro Lagerblad de Oliveira +4 more
TL;DR: Mechanisms by which heme can exert biological damage, together with a wide spectrum of adaptations developed by blood-feeding insects and ticks to counteract its deleterious effects are reviewed.
Related Papers (5)
The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties.
Stefan W. Ryter,Rex M. Tyrrell +1 more