High-resolution phased-array MRI of the human brain at 7 tesla: Initial experience in multiple sclerosis patients
Meredith Metcalf,Duan Xu,Darin T. Okuda,Lucas Carvajal,Radhika Srinivasan,Douglas A.C. Kelley,Pratik Mukherjee,Sarah J. Nelson,Daniel B. Vigneron,Daniel Pelletier +9 more
TLDR
In this paper, the authors developed optimized high-resolution 7T MRI techniques using high sensitivity, specialized phasedarray coils, for improved gray matter (GM) and white matter differentiation, in an effort to improve visualization of multiple sclerosis (MS) lesions in vivo.Abstract:
Recent advancement for magnetic resonance imaging (MRI) involves the incorporation of higher-field strengths. Although imagers with higher magnetic field strengths were developed and tested in research labs, the direct application to patient MR studies have been extremely limited. Imaging at 7 Tesla (7T) affords advantages in signal-to-noise ratio and image contrast and resolution; however, these benefits can only be realized if the correct coils exist to capture the images. The objective of this study was to develop optimized high-resolution 7T MRI techniques using high sensitivity, specialized phased-array coils, for improved gray matter (GM) and white matter differentiation, in an effort to improve visualization of multiple sclerosis (MS) lesions in vivo. Twenty-three subjects were enrolled in this preliminary study, 17 with clinically definite MS (11 females, 6 males; mean age 43.4 years; range 22-64 years) and 6 healthy controls (2 females, 4 males; mean age 39.0 years; range 27-67 years). MR imaging of MS patients at 7T was demonstrated to be safe, well tolerated, and provided high-resolution anatomical images allowing visualization of structural abnormalities localized near or within the cortical layers. Clear involvement of the GM was observed with improved morphological detail in comparison to imaging at lower-field strength.read more
Citations
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Journal ArticleDOI
Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla
Francesca Bagnato,Simon Hametner,Bing Yao,Peter van Gelderen,Hellmut Merkle,Fredric K. Cantor,Hans Lassmann,Jeff H. Duyn +7 more
TL;DR: This combined imaging and pathological study shows that multi-gradient echo magnetic resonance imaging is a sensitive technique for the identification of iron in the brain tissue of patients with multiple sclerosis and can shed light on the pathological processes when coupled with topographical information and patient disease history.
Journal ArticleDOI
Imaging Cortical Lesions in Multiple Sclerosis With Ultra–High-Field Magnetic Resonance Imaging
David Pitt,Aaron Boster,Wei Pei,Eric S. Wohleb,Adam Jasne,Cherian Renil Zachariah,Kottil Rammohan,Michael V. Knopp,Petra Schmalbrock +8 more
TL;DR: The potential of T2*GRE and white matter-attenuated TFE sequences in ultra-high-field magnetic resonance imaging for cortical lesion detection in patients with multiple sclerosis is indicated.
Journal ArticleDOI
7-T MR—from research to clinical applications?
TL;DR: Examples are given to demonstrate the advantages of susceptibility‐weighted imaging, time‐of‐flight MR angiography, high‐resolution functional MRI, 1H and 31P MRSI in the human brain, sodium and functional imaging of cartilage and the first results using an eight‐channel body array, suggesting future areas of research should be intensified in order to fully explore the potential of 7‐T MR systems for use in clinical diagnosis.
Journal ArticleDOI
Association of Cortical Lesion Burden on 7-T Magnetic Resonance Imaging With Cognition and Disability in Multiple Sclerosis
Daniel M. Harrison,Daniel M. Harrison,Snehashis Roy,Jiwon Oh,Jiwon Oh,Izlem Izbudak,Dzung L. Pham,Susan M. Courtney,Brian Caffo,Craig K. Jones,Craig K. Jones,Peter C.M. van Zijl,Peter C.M. van Zijl,Peter A. Calabresi +13 more
TL;DR: To evaluate the clinical relevance of measures of CL burden derived from high-field magnetic resonance imaging (MRI) in multiple sclerosis, an observational clinical imaging study conducted at an academic MS center found that increasing log[CL volume] conferred a 3-fold increase in the odds of cognitive impairment.
Journal ArticleDOI
Increased cortical grey matter lesion detection in multiple sclerosis with 7 T MRI : a post-mortem verification study
Iris D. Kilsdonk,Laura E. Jonkman,Roel Klaver,Susanne J. van Veluw,Jaco J.M. Zwanenburg,Joost P.A. Kuijer,Petra J. W. Pouwels,Jos W. R. Twisk,Mike P. Wattjes,Peter R. Luijten,Frederik Barkhof,Jeroen J. G. Geurts +11 more
TL;DR: The aim of this study was to determine the sensitivity of 7 T versus 3 T magnetic resonance imaging pulse sequences for the detection of cortical multiple sclerosis lesions by directly comparing them to histopathology.
References
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