Journal ArticleDOI
HLA-B27-Associated Cardiac Disease
TLDR
An HLA-B27-associated cardiac syndrome is identified that consists of severe cardiac conduction system abnormalities and lone aortic regurgitation; the link between this syndrome and HLA -B27 is almost as strong as the links between ankylosing spondylitis and Hla-B 27.Abstract:
Purpose: To review the available information about cardiac disease in relation to the immunogenetic marker HLA-B27 and the inflammatory disorders associated with it (seronegative spondyloarthropath...read more
Citations
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Journal ArticleDOI
Update on Spondyloarthropathies
TL;DR: Study from western Europe indicate that ankylosing spondyloarthropathies in its full spectrum is much more common than previously realized, and its overall prevalence may be similar to that of rheumatoid arthritis (Table 4) (31-33).
Journal ArticleDOI
Cardiovascular risk profile of patients with spondylarthropathies, particularly ankylosing spondylitis and psoriatic arthritis.
TL;DR: Rheumatologists should be aware of the enhanced cardiovascular risk in patients with ankylosing spondylitis and psoriatic arthritis, and modifiable cardiovascular risk factors are identified, which could ultimately result in a lower cardiovascular morbidity and mortality.
Journal ArticleDOI
Inflammatory disease in HLA-B27 transgenic rats
Joel D. Taugor,Shanna D. Maika,Nimman Satumtira,Martha L. Dorris,Ian Lochlan McLean,Hiromi Yanagisawa,Alain Sayad,Andrew J. Stagg,Graham M. Fox,Anne Le O'Brein,Muhammad I. Rehman,Ming Zhou,Allison L. Weiner,Judy B. Splawski,James A. Richardson,Robert E. Hammer +15 more
TL;DR: The spondyloarthropathy‐like disease in rats is specific for HLA‐B27 but does not require Cys67, and Arthritis but not colitis is particularly sensitive to B27 peptide‐binding specificity.
Journal ArticleDOI
Increased risk of cardiovascular and cerebrovascular diseases in individuals with ankylosing spondylitis: a population-based study.
Shelagh M. Szabo,Adrian R. Levy,Sumati R. Rao,Stephanie E. Kirbach,Diane Lacaille,Mary Cifaldi,Walter P. Maksymowych +6 more
TL;DR: Compared with the general population, patients with ankylosing spondylitis are at increased risk for many types of cardiovascular and cerebrovascular diseases, and are more likely to be hospitalized for these diseases.
Journal Article
Ankylosing spondylitis--cardiac manifestations.
D Lautermann,Jürgen Braun +1 more
TL;DR: There is a definite association of heart disease with ankylosing spondylitis (AS), but the magnitude of this relationship is less clear and HLA B27-related heart disease does not seem to be associated with increased mortality.
References
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Journal ArticleDOI
Ankylosing spondylitis and hl-a 27
TL;DR: Using a standard microcytotoxicity technique of tissue typing, the HL-A 27 antigen was identified in 72 out of 75 patients with classical ankylosing spondylitis and in 3 out of75 controls.
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High Association of an HL-A Antigen, W27, with Ankylosing Spondylitis
TL;DR: The frequencies of 24 HL-A antigens were examined in patients with ankylosing spondylitis, 119 with rheumatoid arthritis, and 66 with gout, finding no significant deviation from control frequen...
Journal ArticleDOI
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders
TL;DR: It is established that B27 plays a central role in the pathogenesis of the multi-organ system processes of the spondyloarthropathies and elucidation of the role of B27 should be facilitated by this transgenic model.
Journal ArticleDOI
Associations between ankylosing spondylitis, psoriatic arthritis, Reiter's disease, the intestinal arthropathies, and Behcet's syndrome.
Journal ArticleDOI
Guilt by association: HLA-B27 and ankylosing spondylitis
Richard J. Benjamin,Peter Parham +1 more
TL;DR: New data on the structure and function of HLA class I molecules are synthesized into possible mechanisms that might underly the pathogenesis of AS.