Journal ArticleDOI
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders
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TLDR
It is established that B27 plays a central role in the pathogenesis of the multi-organ system processes of the spondyloarthropathies and elucidation of the role of B27 should be facilitated by this transgenic model.About:
This article is published in Cell.The article was published on 1990-11-30. It has received 1133 citations till now. The article focuses on the topics: Transgenic Model & HLA-B27.read more
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The immunological and genetic basis of inflammatory bowel disease.
G. Bouma,G. Bouma,Warren Strober +2 more
TL;DR: The most important finding is the identification of mutations in the gene that encodes NOD2 (nucleotide-binding oligomerization domain 2) protein in a subgroup of patients with Crohn's disease.
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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.
TL;DR: The data provide evidence for a primary role of the immune system in the etiology of ulcerative colitis and strongly suggest that the disease results from an abnormal immune response to a normal antigenic stimulus.
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Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
J. Keffer,Lesley Probert,H. Cazlaris,Spiros Georgopoulos,E. Kaslaris,D. Kioussis,George Kollias +6 more
TL;DR: A direct involvement of TNF in the pathogenesis of arthritis is indicated and transgenic mice which predictably develop arthritis represent a novel genetic model by which the pathogenic and treatment of this disease in humans may be further investigated.
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The immunology of mucosal models of inflammation.
TL;DR: This work analyzes the immunology of the IBDs through the lens of the murine models, first by drawing attention to their common features and then by considering individual models at a level of detail necessary to reveal their individual capacities to provide insight into IBD pathogenesis.
References
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Ankylosing spondylitis and hl-a 27
TL;DR: Using a standard microcytotoxicity technique of tissue typing, the HL-A 27 antigen was identified in 72 out of 75 patients with classical ankylosing spondylitis and in 3 out of75 controls.
Book
Natural history of the major histocompatibility complex
TL;DR: The Story TheGene: Organismic approach The Gene: Molecular approach The Protein The Antibody The Cell Function The Population Sociology Evolution Index.
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High Association of an HL-A Antigen, W27, with Ankylosing Spondylitis
TL;DR: The frequencies of 24 HL-A antigens were examined in patients with ankylosing spondylitis, 119 with rheumatoid arthritis, and 66 with gout, finding no significant deviation from control frequen...
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Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs
TL;DR: The overall efficiency of microinjection of foreign DNA into fertilized mammalian eggs depends on the choice of mouse strains; for example, generating transgenic mice that express foreign growth hormone genes is about eight times easier with C57/BL6 X SJL hybrid mice than with inbred C57-BL6 mice.
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Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene
TL;DR: The introduction of the mouse Ren-2 renin gene3,1113 into the genome of the rat is described and it is demonstrated that expression of this gene causes severe hypertension.