Host defense against bacterial endotoxemia: mechanism in normal animals.
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TLDR
Results from the present study are fully consistent with the thesis that circulating plasma represents a principal site of detoxification and that plasma esterases of the nonspecific, carboxylic type are of major concern in defense against circulating endotoxins.Abstract:
The present study defines the early response of normal rabbits to the intravenous injection of a single, sublethal dose of endotoxin. Within the first few hours following endotoxin there occurs in the circulating plasma of recipients a decrease in ionized calcium, a threefold increase in the heat-stable, organo-phosphate-resistant esterase level, and a striking increase in the endotoxin-detoxifying capacity. These results are fully consistent with the thesis that circulating plasma represents a principal site of detoxification and that plasma esterases of the nonspecific, carboxylic type are of major concern in defense against circulating endotoxins.read more
Citations
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The role of endotoxin in liver injury.
TL;DR: Evidence is present that a common pathway for hepatic injury by a variety of agents may result from impairment of the liver's ability to detoxify bacterial endotoxins from the gastrointestinal tract.
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Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins
TL;DR: The experiments suggest that serum lipoproteins control endotoxin-induced monocyte activation and monokine release, and the LPS-inactivating capacity of serum was shown to be a function of the lipoproteinins.
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Interaction of lipopolysaccharides with plasma high-density lipoprotein in rats.
TL;DR: Results may indicate that HDL represents a transport protein for LPS in plasma to organs of clearance or to other cellular targets.
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The modification of biophysical and endotoxic properties of bacterial lipopolysaccharides by serum.
TL;DR: Normal rabbit serum reduces the buoyant density of lipopolysaccharide from Escherichia coli 0111:B4 and Salmonella minnesota R595 to a value less than g/cm3, and preliminary evidence suggests that the density shift does not occur as a result of the degradation of the glycolipid backbone of the LPS.
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The role of sodium and calcium ions in the hypothalamus in the control of body temperature of the unanaesthetized cat
R. D. Myers,W. L. Veale +1 more
TL;DR: Isolated regions of the anterior, posterior and other areas of the hypothalamus of the cortex of the unanaesthetized cat were perfused by means of push‐pull cannulae lowered through permanently implanted guide tubes.
References
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Journal ArticleDOI
Serum Lipids in Infection
TL;DR: Lipoprotein electrophoresis demonstrated that the hyperlipidemia in patients with severe infection caused by gram-negative bacilli was related to increased levels of pre-beta-lipoproteins, which resulted from increased concentrations of serum triglycerides and free cholesterol.
Journal ArticleDOI
Hyperlipidemia, fatty liver, and bromsulfo-phthalein retention in rabbits injected intravenously with bacterial endotoxins
TL;DR: No direct correlation could be established between the serum lipid levels and the extent and distribution of intravascular thrombosis and necrosis in the lungs, liver, and spleen, or the production of the generalized Shwartzman phenomenon in the kidney, but there appeared to be a direct correlation between the elevated serum triglyceride levels and