Journal ArticleDOI
Human aldehyde dehydrogenase E3 isozyme is a betaine aldehyde dehydrogenase.
Ming-Kai Chern,Regina Pietruszko +1 more
TLDR
Activity with betaine aldehyde was considerably higher than that with 4-aminobutyraldehyde, the best known substrate, and human E3 isozyme and betaineAldehyde dehydrogenase are the same enzyme.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1995-08-15. It has received 74 citations till now. The article focuses on the topics: Betaine-aldehyde dehydrogenase activity & Betaine-aldehyde dehydrogenase.read more
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Journal ArticleDOI
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.
TL;DR: What is currently known about each member of the human ALDH superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation, is presented including the pathophysiological significance of these enzymes.
Journal ArticleDOI
Carnitine biosynthesis in mammals.
TL;DR: This review aims to cover the current knowledge of the enzymological, molecular, metabolic and regulatory aspects of mammalian carnitine biosynthesis, with an emphasis on the human and rat.
Journal ArticleDOI
Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology
TL;DR: The strongest correlations found to date have been those between the ALDH2*2 allele and cancers of the oro-pharynx and oesophagus, and it will be important to replicate other interesting associations between these variants and other cancers and heart disease, and to determine the biochemical mechanisms underlying the associations.
Journal ArticleDOI
Genetic engineering of glycinebetaine production toward enhancing stress tolerance in plants: metabolic limitations.
Jun Huang,Rozina Hirji,Luc Adam,Kevin L. Rozwadowski,Joe Hammerlindl,Wilf Keller,Gopalan Selvaraj +6 more
TL;DR: The need to enhance the endogenous choline supply to support accumulation of physiologically relevant amounts of betaine is demonstrated, as a moderate stress tolerance was noted in some but not all betaine-producing transgenic lines based on relative shoot growth.
Journal ArticleDOI
Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
TL;DR: The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily, enzymes that oxidize a wide range of aldehydes to their corresponding carboxylic acids.
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