Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study.
Rolando Herrero,Xavier Castellsagué,Michael Pawlita,Jolanta Lissowska,Frank Kee,Prabda Balaram,Thangarajan Rajkumar,Sridhar H,Barbara Rose,Javier Pintos,Leticia Fernandez,A.M. Idris,María José Sánchez,Adoración Nieto,Renato Talamini,Alessandra Tavani,F. Xavier Bosch,Ulrich Reidel,Peter J.F. Snijders,Chris J.L.M. Meijer,Raphael P. Viscidi,Nubia Muñoz,Silvia Franceschi +22 more
TLDR
HPV appears to play an etiologic role in many cancers of the oropharynx and possibly a small subgroup of cancers of The most common HPV type in genital cancers (HPV16) was also the most common in these tumors.Abstract:
= 1.5, 95% CI = 1.1 to 2.1) and the oropharynx (OR = 3.5, 95% CI = 2.1 to 5.9). Antibodies against HPV16 E6 or E7 were also associated with risk for cancers of the oral cavity (OR = 2.9, 95% CI = 1.7 to 4.8) and the oropharynx (OR = 9.2, 95% CI = 4.8 to 17.7). CONCLUSIONS: HPV appears to play an etiologic role in many cancers of the oropharynx and possibly a small subgroup of cancers of the oral cavity. The most common HPV type in genital cancers (HPV16) was also the most common in these tumors. The mechanism of transmission of HPV to the oral cavity warrants further investigation.read more
Citations
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Journal ArticleDOI
Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States
Anil K. Chaturvedi,Eric A. Engels,Ruth M. Pfeiffer,Brenda Y. Hernandez,Weihong Xiao,Esther Kim,Bo Jiang,Marc T. Goodman,Maria Sibug-Saber,Wendy Cozen,Lihua Liu,Charles F. Lynch,Nicolas Wentzensen,Richard C.K. Jordan,Sean F. Altekruse,William F. Anderson,Philip S. Rosenberg,Maura L. Gillison +17 more
TL;DR: In this article, the prevalence of human papillomavirus (HPV) infection in oropharyngeal cancer was determined for all 271 oropharygeal cancers (1984-2004) collected by the three population-based cancer registries in the Surveillance, Epidemiology, and End Results (SEER) Residual Tissue Repositories Program.
Journal ArticleDOI
The global health burden of infection-associated cancers in the year 2002.
TL;DR: The fraction of the different types of cancer, and of all cancers worldwide and in different regions, has been estimated using several methods; primarily by reviewing the evidence for the strength of the association (relative risk) and the prevalence of infection in different world areas.
Journal ArticleDOI
Global epidemiology of oral and oropharyngeal cancer
TL;DR: This review presents data on incidence, mortality, survival and trends in cancers of the lip, oral cavity and oropharynx using available recent data sources around the world to gain insight into the geographic variations in the incidence of this cancer in the globe.
Journal ArticleDOI
Case-control study of human papillomavirus and oropharyngeal cancer.
Aimée R. Kreimer,Raphael P. Viscidi,Michael Pawlita,Carole Fakhry,Wayne M. Koch,William H. Westra,Maura L. Gillison +6 more
TL;DR: Oropharyngeal cancer was significantly associated with oral HPV type 16 (HPV-16) infection, and the degree of association increased with the number of vaginal-sex and oral-sex partners, among subjects with or without the established risk factors of tobacco and alcohol use.
Journal ArticleDOI
Improved Survival of Patients With Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial
Carole Fakhry,William H. Westra,S. Li,Anthony J. Cmelak,John A. Ridge,Harlan A. Pinto,Arlene A. Forastiere,Maura L. Gillison +7 more
TL;DR: For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with therapeutic response and survival and, after adjustment for age, tumor stage, and ECOG performance status, lower risks of progression and death are found.
References
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AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Journal ArticleDOI
The causal relation between human papillomavirus and cervical cancer
TL;DR: It is the right time for medical societies and public health regulators to consider the causal role of human papillomavirus infections in cervical cancer and to define its preventive and clinical implications.
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.