Human thalamic and cortical activities assessed by dimension of activation and spectral edge frequency during sleep wake cycles.
Marc Rey,Hélène Bastuji,Luis Garcia-Larrea,Philippe Guillemant,François Mauguière,Michel Magnin +5 more
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TLDR
DA analysis proved reliable for quantification of cortical activity, in agreement with data issued from classical vigilance states scoring and spectral analysis.Abstract:
Study objectives: Using spectral edge frequency (SEF 95 ) and dimension of activation (DA), a new tool derived from the dimension of correlation, we assessed the activation of thalamus and cortex in the different vigilance states. Patients: Results were gathered from intracerebral recordings performed in 12 drug-resistant epileptic patients during video-stereoelectroencephalographic (SEEG) monitoring. Results: In the cortex, we observed a progressive decrease of DA from wake to sleep, with minimal DA values characterizing the deep slow wave sleep (dSWS) stage. During paradoxical sleep (PS), cortical level of activity returned to DA values similar to those obtained during wakefulness. In the thalamus, DA values during wakefulness were higher than the values observed during light SWS (lSWS), deep SWS (dSWS) and PS; there were no significant differences between the 3 sleep stages. Similar variations were observed with SEF 95 . Conclusion: DA analysis proved reliable for quantification of cortical activity, in agreement with data issued from classical vigilance states scoring and spectral analysis. At the thalamic level, only 2 levels of activity within a sleep wake cycle were observed, pointing to dissociated levels of activation between the thalamus and the neocortex during lSWS and PS.read more
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Thalamic deactivation at sleep onset precedes that of the cerebral cortex in humans
Michel Magnin,Marc Rey,Hélène Bastuji,Philippe Guillemant,François Mauguière,Luis Garcia-Larrea +5 more
TL;DR: Using simultaneous intracortical and intrathalamic recordings, it is demonstrated that the thalamic deactivation occurring at sleep onset most often precedes that of the cortex by several minutes, whereas reactivation of both structures during awakening is synchronized.
Journal ArticleDOI
Temporal Disorganization of Circadian Rhythmicity and Sleep-Wake Regulation in Mechanically Ventilated Patients Receiving Continuous Intravenous Sedation
Brian K. Gehlbach,Florian Chapotot,Rachel Leproult,Harry Whitmore,Jason T. Poston,Mark C. Pohlman,Annette Miller,Anne S. Pohlman,Arlet Nedeltcheva,John Jacobsen,Jesse B. Hall,Eve Van Cauter +11 more
TL;DR: The finding that most subjects exhibited preserved, but phase delayed, excretion of aMT6s suggests that the circadian pacemaker of such patients may be free-running, and the circadian rhythms of patients receiving mechanical ventilation and intravenous sedation exhibit pronounced temporal disorganization.
Journal ArticleDOI
Modeling Resting-State Functional Networks When the Cortex Falls Asleep: Local and Global Changes
TL;DR: Large-scale modeling of the human cortico-cortical anatomical connectivity is employed to evaluate changes in resting-state FC when the model "falls asleep" due to the progressive decrease in arousal-promoting neuromodulation, and it is shown that local slow waves are structured macroscopically in networks that resemble the resting- state networks.
Journal ArticleDOI
Heterogeneity of arousals in human sleep: A stereo-electroencephalographic study
TL;DR: The results suggest that the human cortex does not shift from sleep to wake in an abrupt binary way, and stereotyped arousals at the thalamic level seem to be associated with different patterns of cortical arousals due to various regulation factors.
Journal ArticleDOI
Filtering the reality: Functional dissociation of lateral and medial pain systems during sleep in humans
Hélène Bastuji,Stéphanie Mazza,Caroline Perchet,Caroline Perchet,Maud Frot,Maud Frot,François Mauguière,François Mauguière,Michel Magnin,Michel Magnin,Luis Garcia-Larrea,Luis Garcia-Larrea +11 more
TL;DR: While the lateral operculo‐insular system subserving sensory analysis of somatic stimuli remained active during paradoxical‐REM sleep, mid‐anterior cingulate processes related to orienting and avoidance behavior were suppressed, explaining why nociceptive stimuli can be either neglected or incorporated into dreams without awakening the subject.
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