Journal ArticleDOI
Hydrogen bridges in crystal engineering: interactions without borders.
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TLDR
The aim of this article is to highlight some features common to all hydrogen bonds and further to suggest that the term hydrogen bridge is perhaps a better descriptor for them.Abstract:
A hydrogen bond, X-H...A, is an interaction wherein a hydrogen atom is attracted to two atoms, X and A, rather than just one and so acts like a bridge between them. This attraction always increases with increasing electronegativity of X and A, and in the classical view all hydrogen bonds are highly electrostatic and sometimes even partly covalent. Gradually, the concept of a hydrogen bond became more relaxed to include weaker interactions, provided some electrostatic character remains. In the limit, these weak hydrogen bonds have considerable dispersive-repulsive character and merge into van der Waals interactions. A great variety of hydrogen bonds are observed in the solid state and the aim of this article is to highlight some features common to all these bonds and further to suggest that the term hydrogen bridge is perhaps a better descriptor for them. Such a description recognizes an interaction without borders and one that admits of much variation in its relative covalent, electrostatic, and van der Waals content.read more
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Novel tools for visualizing and exploring intermolecular interactions in molecular crystals.
TL;DR: A new way of exploring packing modes and intermolecular interactions in molecular crystals is described, using Hirshfeld surfaces to partition crystal space, using identifiable patterns of interaction between small molecules to rationalize the often complex mix of interactions displayed by large molecules.
Journal ArticleDOI
CH/π hydrogen bonds in crystals
TL;DR: The CH/π interaction is a kind of hydrogen bond operating between a soft acid CH and a soft base π-system (double and triple bonds, C6 and C5 aromatic rings, heteroaromatics, convex surfaces of fullerenes and nanotubes) as discussed by the authors.
Journal ArticleDOI
A Medicinal Chemist’s Guide to Molecular Interactions
TL;DR: This article compile and review the literature on molecular interactions as it pertains to medicinal chemistry through a combination of careful statistical analysis of the large body of publicly available X-ray structure data and experimental and theoretical studies of specific model systems.
Journal ArticleDOI
What is the covalency of hydrogen bonding
TL;DR: The decomposition of the interaction energy is useful to analyze hydrogen bonding and particularly to answer the question of what does the covalency of hydrogen bonding mean.
Journal ArticleDOI
Organic fluorine compounds: a great opportunity for enhanced materials properties.
TL;DR: It is shown how application of fluorination is used to enable a number of reactions, to improve materials properties and even open up new fields of research.
References
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MonographDOI
Supramolecular Chemistry: Concepts and Perspectives
TL;DR: From molecular to supramolescular chemistry: concepts and language of supramolecular chemistry, molecular recognition, information, complementarity molecular receptors - design principles and more.
Journal ArticleDOI
The C-h···o hydrogen bond: structural implications and supramolecular design.
TL;DR: It is clearly no longer necessary to justify the relevance of C-H’‚‚O hydrogen bonds, so widely invoked are they in small-molecule and biological crystallography and supramolecular synthesis and crystal engineering.
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