Journal ArticleDOI
Hypertriglyceridemia, insulin resistance, and the metabolic syndrome.
TLDR
Various therapeutic approaches for the patient with the metabolic syndrome should be implemented to decrease the risk of cardiovascular disease events, including decreasing obesity, increasing physical activity, and managing dyslipidemia.Abstract:
The metabolic syndrome consists of a cluster of metabolic disorders, many of which promote the development of atherosclerosis and increase the risk of cardiovascular disease events. Insulin resistance may lie at the heart of the metabolic syndrome. Elevated serum triglycerides commonly associate with insulin resistance and represent a valuable clinical marker of the metabolic syndrome. Abdominal obesity is a clinical marker for insulin resistance. The metabolic syndrome manifests 4 categories of abnormality: atherogenic dyslipidemia (elevated triglycerides, increased small low-density lipoproteins, and decreased high-density lipoproteins), increased blood pressure, elevated plasma glucose, and a prothrombotic state. Various therapeutic approaches for the patient with the metabolic syndrome should be implemented to decrease the risk of cardiovascular disease events. These interventions include decreasing obesity, increasing physical activity, and managing dyslipidemia; the latter may require the use of pharmacotherapy with cholesterol-lowering and triglyceride-lowering drugs.read more
Citations
More filters
Journal ArticleDOI
Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
TL;DR: These results from a representative sample of US adults show that the metabolic syndrome is highly prevalent and the large numbers of US residents with the metabolic Syndrome may have important implications for the health care sector.
Prevalence and Associated Risk Factor Findings in the US Population From the Third National Health and Nutrition Examination Survey, 1988-1994
Yong-Woo Park,Shankuan Zhu,Latha Palaniappan,Stanley Heshka,Mercedes R. Carnethon,Steven B. Heymsfield +5 more
TL;DR: For example, this article found that older age, postmenopausal status, Mexican American ethnicity, higher body mass index, current smoking, low household income, high carbohydrate intake, no alcohol consumption, and physical inactivity were associated with increased odds of metabolic syndrome.
Journal ArticleDOI
The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population From the Third National Health and Nutrition Examination Survey, 1988-1994
Yong Woo Park,Shankuan Zhu,Latha Palaniappan,Stanley Heshka,Mercedes R. Carnethon,Steven B. Heymsfield,Steven B. Heymsfield +6 more
TL;DR: Older age, postmenopausal status, Mexican American ethnicity, higher body mass index, current smoking, low household income, high carbohydrate intake, no alcohol consumption, and physical inactivity were associated with increased odds of the metabolic syndrome.
Journal ArticleDOI
The PPARs: from orphan receptors to drug discovery.
Journal ArticleDOI
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD).
Lars Rydén,Eberhard Standl,Malgorzata Bartnik,Greet Van den Berghe,John Betteridge,Menko-Jan de Boer,Francesco Cosentino,Bengt Jönsson,Markku Laakso,Klas Malmberg,Silvia G. Priori,Jan Östergren,Jaakko Tuomilehto,Inga Thrainsdottir,Ilse Vanhorebeek,Marco Stramba-Badiale,Peter Lindgren,Qing Qiao,Silvia G. Priori,Jean-Jacques Blanc,Andrzej Budaj,John Camm,Veronica Dean,Jaap W. Deckers,Kenneth Dickstein,John Lekakis,Keith McGregor,Marco Metra,João Morais,Ady Osterspey,Juan Tamargo,José Luis Zamorano,J.W. Deckers,Michel E. Bertrand,Bernard Charbonnel,Erland Erdmann,Ele Ferrannini,Allan Flyvbjerg,Helmut Gohlke,Jose Ramon Gonzalez Juanatey,Ian D. Graham,Pedro Filipe Monteiro,Klaus G. Parhofer,Kalevi Pyörälä,Itamar Raz,Guntram Schernthaner,Massimo Volpe,David Wood +47 more
TL;DR: Guidelines and Expert Consensus documents aim to present management and recommendations based on all of the relevant evidence on a particular subject in order to help physicians to select the best possible management strategies for the individual patient, suffering from a specific condition, taking into account not only the impact on outcome, but also the risk benefit ratio of a particular diagnostic or therapeutic procedure.
References
More filters
Journal ArticleDOI
Prediction of Coronary Heart Disease Using Risk Factor Categories
Peter W.F. Wilson,Ralph B. D'Agostino,Daniel Levy,Albert M. Belanger,Halit Silbershatz,William B. Kannel +5 more
TL;DR: A simple coronary disease prediction algorithm was developed using categorical variables, which allows physicians to predict multivariate CHD risk in patients without overt CHD.
Journal Article
Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults : the evidence report
Journal ArticleDOI
Quantification of coronary artery calcium using ultrafast computed tomography
Arthur S. Agatston,Warren R. Janowitz,Warren R. Janowitz,Frank J. Hildner,Frank J. Hildner,N R Zusmer,N R Zusmer,Manuel Viamonte,Manuel Viamonte,Robert Detrano,Robert Detrano +10 more
TL;DR: In this article, the authors used ultrafast computed tomography (UCT) to detect and quantify coronary artery calcium levels in 584 subjects (mean age 48 +/- 10 years) with and without clinical coronary artery disease.
Journal ArticleDOI
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
TL;DR: In summary, insulin resistance appears to be a syndrome that is associated with a clustering of metabolic disorders, including non-insulin-dependent diabetes mellitus, obesity, hypertension, lipid abnormalities, and atherosclerotic cardiovascular disease.
Journal ArticleDOI
Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: Executive summary
F. X. Pi-Sunyer,Diane M. Becker,Claude Bouchard,Richard A. Carleton,Graham A. Colditz,William H. Dietz,John P. Foreyt,R. J. Garrison,Scott M. Grundy,Barbara C. Hansen,Millicent Higgins,James O. Hill,Barbara V. Howard,Robert J. Kuczmarski,Shiriki K. Kumanyika,R. D. Legako,T. E. Prewitt,A. P. Rocchini,Philip L. Smith,Linda Snetselaar,James R. Sowers,M. Weintrub,Don Williamson,G. T. Wilson,Clinton D. Brown,Karen A. Donato,Nancy D. Ernst,D. R. Hill,Michael J. Horan,Van S. Hubbard,J. P. Kiley,Eva Obarzanek,D. Shriger,E. Chiquette +33 more
Related Papers (5)
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more