Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
Ronald D. Vale,Ronald D. Vale,Ronald D. Vale,Thomas S. Reese,Michael P. Sheetz,Michael P. Sheetz +5 more
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TLDR
The partial purification of a protein from squid giant axons and optic lobes that induces microtubule-based movements is reported and there is a homologous protein in bovine brain, for which the name kinesin is proposed.About:
This article is published in Cell.The article was published on 1985-08-01 and is currently open access. It has received 1893 citations till now. The article focuses on the topics: Dynein & Kinesin light chain 1.read more
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Complementary DNA sequencing : expressed sequence tags and human genome project
Mark Raymond Adams,Jenny M. Kelley,Jeannine D. Gocayne,Mark Dubnick,Mihael H. Polymeropoulos,Hong Xiao,Carl R. Merril,Andrew Wu,Bjorn Olde,Ruben F. Moreno,Anthony R. Kerlavage,W. Richard McCombie,J. Craig Venter +12 more
TL;DR: Automated partial DNA sequencing was conducted on more than 600 randomly selected human brain complementary DNA (cDNA) clones to generate expressed sequence tags (ESTs), which will facilitate the tagging of most human genes in a few years at a fraction of the cost of complete genomic sequencing.
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Translocation of Inhaled Ultrafine Particles to the Brain
Günter Oberdörster,Zachary D. Sharp,Viorel Atudorei,Alison Elder,Robert Gelein,Wolfgang G. Kreyling,Christopher Cox +6 more
TL;DR: The study concludes that the central nervous system (CNS) can be targeted by airborne solid ultrafine particles and that the most likely mechanism is from deposits on the olfactory mucosa of the nasopharyngeal region of the respiratory tract and subsequent translocation via the Olfactory nerve.
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The Molecular Motor Toolbox for Intracellular Transport
TL;DR: Remarkably, fungi, parasites, plants, and animals have distinct subsets of Toolbox motors in their genomes, suggesting an underlying diversity of strategies for intracellular transport.
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Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport
TL;DR: This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins.
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Kinesin superfamily motor proteins and intracellular transport
TL;DR: The mechanisms by which different kinesin recognize and bind to specific cargos, as well as how kinesins unload cargo and determine the direction of transport, have now been identified and open exciting new areas of kinesIn research.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin.
TL;DR: Tau is sufficient for both nucleation and elongation of microtubules from purified tubulin and hence the reconstituted tau + tubulin system defines a complete microtubule assembly system under standard buffer conditions.
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A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs).
TL;DR: Results indicate that MAP 1 and MAP2, as well as other MAP species, may have a different cellular or subcellular distribution.