Journal ArticleDOI
Improved Accuracy in Automated Fluorometric Determination of Plasma Triglycerides
TLDR
Accuracy of the automated fluorometric measurement of triglyceride by the technique of Kessler and Lederer is limited by the instability of the baseline, so a relatively inexpensive fluorometer with the solid-state photomultiplier microphotometer was used to increase precision of measurements.Abstract:
Accuracy of the automated fluorometric measurement of triglyceride by the technique of Kessler and Lederer is limited by the instability of the baseline. Concentration of the alcoholic KOH reagent was modified, and the pump tube manifold altered to provide on-stream mixing of the KOH reagent, which overcame this difficulty. A relatively inexpensive fluorometer with the solid-state photomultiplier microphotometer, modified to provide dual-scale sensitivity, was used to increase precision of measurements. Analytical results for 30 serum samples, taken from three pools of frozen serum, show the accuracy of the measurements to be ±8 mg/100 ml and the standard deviation ±9 mg/100 ml for a single determination.read more
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A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.
TL;DR: The observation in otherwise clinically healthy subjects of hypertriglyceridemia, reduced HDL-cholesterol, and marked apoprotein abnormalities, without a significant incidence of atherosclerotic disease in the family suggests this is a new disease entity in the field of lipoprotein pathology.
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Soybean-protein diet in the treatment of type-II hyperlipoproteinaemia.
TL;DR: The hypothesis that a soy protein has a hypocholesterolaemic action per se is supported by the results of a subsequent experiment in 8 type-II patients in whom the addition of cholesterol (500 mg/day) to soy protein did not modify the hypocholesterololaemic response.
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The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.
TL;DR: Results indicate that the proliferation of smooth muscle cells is dramatically inhibited by reduction of platelets, in contrast to normal sheep sera-treated animals which showed a mean intimal thickness of 18 cell layers within 28 days often after de-endothelialization.
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Effects of lipoproteins on plasma viscosity
TL;DR: Viscosity increases of the magnitude demonstrated may in turn alter blood flow and thus contribute to symptoms such as intermittent claudication, and indicate that chylomicrons in particular can increase plasma viscosity.
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Three-pool model of the long-term turnover of plasma cholesterol in man
TL;DR: The long-term turnover of plasma cholesterol was examined in six men injected intravenously with [4-(14)C]cholesterol and the results indicate that the turnover curves of all six subjects conformed to, and could be satisfactorily described by, a three-pool model.