Open AccessJournal Article
In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells
TLDR
The authors showed that host H-2 antigens do exert an effect on the specificity of T-cell responses, and that CTL from a normal mouse can respond quantitatively as well to antigen plus foreign H 2 in addition to self H 2.Abstract:
CELL membrane structures controlled by genes in the major histocompatibility complex (H–2 in mice) are involved in most immune interactions between T lymphocytes and other cells1. Cytotoxic T lymphocytes (CTL) immunised against viruses2, haptens3, minor histocompatibility antigens4 or tumour antigens5, are specific for self H–2 antigens as well as for the foreign antigen. But CTL are not restricted to recognising antigens in combination with only self H–2. H–2d homozygous CTL which have matured in an irradiated H–2d/H–2k host can respond to antigen plus H–2k in addition to antigen plus H–2d (refs 6–8). It is not known whether the H–2 environment in which T cells mature influences their range of specificity, that is, whether CTL from a normal mouse can respond quantitatively as well to antigen plus foreign H–2 as they do to antigen plus self H–2. These experiments were designed to test this influence. The results suggest that host H–2 antigens do exert an effect on the specificity of T-cell responses.read more
Citations
More filters
Journal ArticleDOI
T cell tolerance by clonal elimination in the thymus
TL;DR: The results show that in normal animals tolerance to self-MHC is due to clonal elimination rather than suppression, and indicate that tolerance induction may occur in the thymus at the time immature thymocytes are selected to move into the mature thymocyte pool.
Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.
TL;DR: Transgenic mice generated with redirected bcl-2 expression protected immature CD4+8+ thymocytes from glucocorticoid, radiation, and anti-CD3-induced apoptosis and altered T cell maturation, resulting in increased percentages of CD3hi and CD4-8+Thymocytes.
Journal ArticleDOI
Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
Alex Yee-Chen Huang,Paul Golumbek,Mojgan Ahmadzadeh,Elizabeth M. Jaffee,Drew M. Pardoll,Hyam I. Levitsky +5 more
TL;DR: MHC class I-restricted antigens are efficiently transferred in vivo to bone marrow-derived antigen-presenting cells, which suggests that human leukocyte antigen matching may be less critical in the application of tumor vaccines than previously thought.
Journal ArticleDOI
The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice
TL;DR: It is shown that, for mice, the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing V beta 3 and V beta 8.3, and few others, demonstrating that tolerance to exogenously administered antigen can be caused by clonal deletion of reactive T cells.
References
More filters
Journal ArticleDOI
T cell tolerance by clonal elimination in the thymus
TL;DR: The results show that in normal animals tolerance to self-MHC is due to clonal elimination rather than suppression, and indicate that tolerance induction may occur in the thymus at the time immature thymocytes are selected to move into the mature thymocyte pool.
Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.
TL;DR: Transgenic mice generated with redirected bcl-2 expression protected immature CD4+8+ thymocytes from glucocorticoid, radiation, and anti-CD3-induced apoptosis and altered T cell maturation, resulting in increased percentages of CD3hi and CD4-8+Thymocytes.
Journal ArticleDOI
Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
Alex Yee-Chen Huang,Paul Golumbek,Mojgan Ahmadzadeh,Elizabeth M. Jaffee,Drew M. Pardoll,Hyam I. Levitsky +5 more
TL;DR: MHC class I-restricted antigens are efficiently transferred in vivo to bone marrow-derived antigen-presenting cells, which suggests that human leukocyte antigen matching may be less critical in the application of tumor vaccines than previously thought.
Journal ArticleDOI
The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice
TL;DR: It is shown that, for mice, the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing V beta 3 and V beta 8.3, and few others, demonstrating that tolerance to exogenously administered antigen can be caused by clonal deletion of reactive T cells.