Open AccessJournal Article
In vitro antiprotozoal activity and cytotoxicity of Microlicia crenulata (DC) Mart extract.
M. do C. Pereira,R. M. de Pádua,R. C. de Paula,Marta Nascimento,Luciana Ferreira Soares,R. G. Isidório,David Lee Nelson +6 more
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TLDR
The ant i- protozoal activity against a chloroquine -resistant Plasmodium falciparum W2 clone was studied by the pLDH method and Acacetin was isolated from the dichloromethane fraction, this being the first report of the occurrence of this flavone in the Microlicia genus.Abstract:
Microlicia crenulata(DC.) Mart (Melastomataceae) has a very restricted occurrence, being considered endem- ic to the state of Minas Gerais, Brazil. To date, the species has been chemically only for taxonomic purposes. The ant i- protozoal activity against a chloroquine -resistant Plasmodium falciparum W2 clone was studied by the pLDH method. Cytotoxic activity was investigated in vitro against the HepG2 A16.cell line. Antiplasmodial activity was exhibited by the dichloromethane fraction, and no cytotoxicity to the HepG2 A16 cell line was observed. Acacetin was isolated from the dichloromethane fraction, this being the first report of the occurrence of this flavone in the Microlicia genus.read more
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Anther wall and pollen development in Neotropical species-rich Miconia (Melastomataceae)
Priscila Andressa Cortez,Priscila Andressa Cortez,Ana Paula Souza Caetano,Sandra Maria Carmello-Guerreiro,Simone de Pádua Teixeira +4 more
TL;DR: This study investigates the anther wall and pollen development in six closely related species of Miconia, and reports for the first time bisporangiate anthers, crystals and proteinoplasts in tapetal cells for Melastomataceae, and ultrastructural features of anther and pollen wall for MiconIA.
Evaluación de la actividad antiplasmodial de las partes aéreas de plantas colectadas en Colombia
Sosa Puerto,Wilmar Esteban +1 more
TL;DR: Las plantas medicinales han sido una fuente muy importante de agentes antimalaricos, tales como the quinina y the artemisinina, y hacen necesaria la busqueda oferta de nuevos farmacos.
References
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Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.
François Denizot,Rita Lang +1 more
TL;DR: The reliability and sensitivity of the test have been increased to the point where it can in many cases replace the [3H]thymidine uptake assay to measure cell proliferation or survival in growth factor or cytotoxicity assays.
Journal ArticleDOI
The Systematic Identification of Flavonoids
Journal ArticleDOI
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Journal ArticleDOI
Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products.
TL;DR: This present review covers most of the recently-published non-alkaloidal natural compounds from plants with antiplasmodial and antimalarial properties, belonging to the classes of terpenes, limonoids, flavonoid, chromones, xanthones, anthraquinones, miscellaneous and related compounds, besides the majority of papers describing antiplAsmodial crude extracts published in the last five years not reviewed before.