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The Systematic Identification of Flavonoids
12 May 1970-
About: The article was published on 1970-05-12 and is currently open access. It has received 3638 citations till now. The article focuses on the topics: Flavonols.
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TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
8,513 citations
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TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Abstract: Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3, or a hydroxyl group in position 3 of the C (middle) ring. These characteristics appear to also be required for best activity, especially antioxidant and antiproliferative, in the systems studied. The particular hydroxylation pattern of the B ring of the flavonoles increases their activities, especially in inhibition of mast cell secretion. Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine. In spite of the voluminous literature available, however, Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional. Suggestions are made where such possibilities may be worth pursuing.
4,663 citations
Cites background from "The Systematic Identification of Fl..."
...The 7-hydroxy group of the flavonoids is considered to be the first to dissociate and is thus the most likely site of attack by peroxyl radical (Mabry et al., 1970; Bors et al., 1990)....
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TL;DR: In this article, two complementary colorimetric methods, aluminum chloride method and 2,4-dini trophenylhydrazine method, were used to determine the real content of total flavonoids in propolis.
3,899 citations
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TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.
2,424 citations
Cites background from "The Systematic Identification of Fl..."
...Prominent examples are Mabry et al. (1970), Markham (1982), Harborne (1988a, 1988b), Bankova et al. (1982, 1987), Pangarova et al. (1980, 1986), Garcia-Viguera et al. (1993), and Bonvehi et al. (1994)....
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TL;DR: This paper provides a summary of background information and methodologies used for the analysis of phenolics in foods and nutraceuticals.
1,490 citations