Journal ArticleDOI
In vitro Combination of Human and Bovine Free Secretory Component with IgA of Various Species
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The free form of the secretory component usually associated with secretory IgA can be isolated from human and bovine milk and combines in vitro with human polymeric myeloma IgA, with mouse myelomas, and with the serum IgA of nine different mammalian species.Abstract:
The free form of the secretory component usually associated with secretory IgA can be isolated from human and bovine milk. These free secretory components of different origin combine in vitro with human polymeric myeloma IgA, with mouse myeloma IgA, and with the serum IgA of nine different mammalian species.read more
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Book ChapterDOI
Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response.
Jiri Mestecky,Jerry R. McGhee +1 more
TL;DR: The impact of new information concerning IgA physiology on the immune system is discussed, which suggests that IgA should not be considered only as an isotype providing specific humoral protection of mucosal surfaces but as an integral component of the entire immune system.
Journal ArticleDOI
Nomenclature of Proteins of Cow's Milk: Fifth Revision
W.N. Eigel,J. E. Butler,C.A. Ernstrom,Harold M. Farrell,V.R. Harwalkar,Robert Jenness,R. Mc L. Whitney +6 more
TL;DR: Because of increased interest in milk proteins of species other than bovine, the Committee suggests that these be identified as homologs of those already characterized in European, Bos taurus , and Indian, Bos indicus , cattle.
Journal ArticleDOI
Generation and assembly of secretory antibodies in plants.
Julian K.-C. Ma,A. Hiatt,Mich B. Hein,Nicholas D. Vine,Fei Wang,P. Stabila,C. van Dolleweerd,Keith E. Mostov,Thomas Lehner +8 more
TL;DR: Transgenic plants may be suitable for large-scale production of recombinant secretory immunoglobulin A for passive mucosal immunotherapy because plant cells also possess the requisite mechanisms for assembly and expression of other complex recombinant protein molecules.
Book ChapterDOI
Biological activities of immunoglobulins of different classes and subclasses.
TL;DR: It has now been shown that the antibodies of the various classes and subclasses differ in their biological activities, and, in the future, one should attempt to determine how frequently restricted immune responses occur and how important such restricted antibody formation is in immune deficiency syndromes.
Journal ArticleDOI
The gut-associated lymphoid system: nature and properties of the large dividing cells
TL;DR: B and T blasts from MLN and TDL have, in contrast to blasts from the peripheral lymph nodes, a marked tendancy to home in the gut, and migrate as well in a graft of fetal intestine as in the recipient's own gut, indicating that this selective accumulation is not the result of a mechanism recognizing antigen absorbed from the gut lumen.
References
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Journal ArticleDOI
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis
Klaus Weber,Mary Osborn +1 more
TL;DR: The results show that the polyacrylamide gel electrophoresis method can be used with great confidence to determine the molecular weights of polypeptide chains for a wide variety of proteins.
Journal ArticleDOI
Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
Journal ArticleDOI
A method of trace iodination of proteins for immunologic studies.
Journal ArticleDOI
Characteristics of an immune system common to certain external secretions
TL;DR: The γ1A present in saliva and colostrum exists largely in the form of higher polymers, the major component of which has a sedimentation coefficient of 11S, and its properties including the local production of a distinctive type of antibody separate it from the "systemic" system responsible for the production of circulating antibody.