Journal ArticleDOI
In vitro corrosion and biocompatibility of binary magnesium alloys
TLDR
It was found that hemolysis and the amount of adhered platelets decreased after alloying for all Mg-1X alloys as compared to the pure magnesium control.About:
This article is published in Biomaterials.The article was published on 2009-02-01. It has received 1174 citations till now. The article focuses on the topics: Magnesium alloy & Magnesium.read more
Citations
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Metallic implant biomaterials
Qizhi Chen,George Anthony Thouas +1 more
TL;DR: In this article, the most critical challenges for metallic implant biomaterials are summarized, with emphasis on the most promising approaches and strategies, and the properties that affect biocompatibility and mechanical integrity are discussed in detail.
Journal ArticleDOI
Degradable biomaterials based on magnesium corrosion
Frank Witte,Frank Witte,Norbert Hort,Carla Vogt,Smadar Cohen,Karl Ulrich Kainer,Regine Willumeit,Frank Feyerabend +7 more
TL;DR: Magnesium and its alloys have been investigated recently by many authors as a suitable biodegradable biomaterial as mentioned in this paper, and the latest achievements and comment on the selection and use, test methods and the approaches to develop and produce magnesium alloys that are intended to perform clinically with an appropriate host response.
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Recent advances on the development of magnesium alloys for biodegradable implants.
TL;DR: This review focuses on the following topics: (i) the design criteria of biodegradable materials; (ii) alloy development strategy; (iii) in vitro performances of currently developed Mg-based alloys; and (iv) in vivo performances of presently developed M g-based implants, especially Mg -based alloy under clinical trials.
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Assessing the corrosion of biodegradable magnesium implants: a critical review of current methodologies and their limitations.
TL;DR: This paper aims to elucidate the main benefits and limitations for each of the major in vitro methodologies used in examining the biodegradation behaviour of Mg and its alloys.
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In vitro studies of biomedical magnesium alloys in a simulated physiological environment: a review.
Yunchang Xin,Tao Hu,Paul K. Chu +2 more
TL;DR: An up-to-date review of the in vitro studies on biomedical magnesium alloys in a simulated physiological environment is provided, specifically discussing corrosion types, degradation rates, corrosion products and impact of the constituents in body fluids on materials degradation.
References
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How useful is SBF in predicting in vivo bone bioactivity
Tadashi Kokubo,Hiroaki Takadama +1 more
TL;DR: Examination of apatite formation on a material in SBF is useful for predicting the in vivo bone bioactivity of a material, and the number of animals used in and the duration of animal experiments can be reduced remarkably by using this method.
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In vivo corrosion of four magnesium alloys and the associated bone response.
Frank Witte,Volker Kaese,Heinz Haferkamp,E. Switzer,Andrea Meyer-Lindenberg,Carl Joachim Wirth,H. Windhagen +6 more
TL;DR: There is a strong rationale that in this research model, high magnesium ion concentration could lead to bone cell activation, and metallic implants made of magnesium alloys degrade in vivo depending on the composition of the alloying elements.
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Corrosion mechanisms of magnesium alloys
Guang-Ling Song,Andrej Atrens +1 more
TL;DR: In this paper, a detailed review of the corrosion mechanisms of magnesium alloys is presented, and the basis for the design of new alloys with improved corrosion properties is provided for improving the corrosion properties.
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Understanding Magnesium Corrosion—A Framework for Improved Alloy Performance
Guang-Ling Song,Andrej Atrens +1 more
TL;DR: In this article, a mechanistic overview of the various types of magnesium corrosion is provided, and a theoretical framework for further, much needed research is provided. But, as stated in the introduction, "There is still vast scope both for better fundamental understanding of corrosion processes, engineering usage of magnesium, and also on the corrosion protection of magnesium alloys in service".
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The development of binary Mg–Ca alloys for use as biodegradable materials within bone
TL;DR: The results of tensile tests and in vitro corrosion tests indicated that Mg-1Ca alloy had the acceptable biocompatibility as a new kind of biodegradable implant material and a solid alloy/liquid solution interface model was proposed to interpret the biocorrosion process and the associated hydroxyapatite mineralization.