Journal ArticleDOI
Inbreeding and genetic diversity in dogs: results from DNA analysis.
Reads0
Chats0
TLDR
This review assesses evidence from DNA analysis to determine whether there is sufficient genetic diversity within breeds to ensure that populations are sustainable in the absence of cross breeding and whether genetic diversity is declining.Abstract:
This review assesses evidence from DNA analysis to determine whether there is sufficient genetic diversity within breeds to ensure that populations are sustainable in the absence of cross breeding and to determine whether genetic diversity is declining. On average, dog breeds currently retain approximately 87% of the available domestic canine genetic diversity. Requirements that breeding stock must be 'clear' for all genetic disorders may firstly place undue genetic pressure on animals tested as being 'clear' of known genetic disorders, secondly may contribute to loss of diversity and thirdly may result in the dissemination of new recessive disorders for which no genetic tests are available. Global exchange of genetic material may hasten the loss of alleles and this practice should be discussed in relation to the current effective population size of a breed and its expected future popularity. Genomic data do not always support the results from pedigree analysis and possible reasons for this are discussed.read more
Citations
More filters
Journal Article
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
Journal Article
Human biochemical genetics
TL;DR: For the next few weeks the course is going to be exploring a field that’s actually older than classical population genetics, although the approach it’ll be taking to it involves the use of population genetic machinery.
Journal ArticleDOI
Allogeneic Transplantation of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets in Canine Critical-Size Supra-Alveolar Periodontal Defect Model.
Yuka Tsumanuma,Takanori Iwata,Atsuhiro Kinoshita,Kaoru Washio,Toshiyuki Yoshida,Azusa Yamada,Ryo Takagi,Masayuki Yamato,Teruo Okano,Yuichi Izumi +9 more
TL;DR: Allogeneic transplantation of PDL-MSC sheets has a potential to become an alternative strategy for periodontal regeneration and was observed in both the autologous and the allogeneic transplants.
Journal ArticleDOI
Population structure and genetic heterogeneity in popular dog breeds in the UK
Richard J. Mellanby,Rob Ogden,Dylan N. Clements,Anne French,Adam Gow,Roger M. Powell,Brendan Corcoran,Johan P. Schoeman,Kim M. Summers +8 more
TL;DR: Analysis of genetic distance between breeds showed significantly different inbreeding coefficients for pairwise comparisons among registered breeds, with the most divergent breeds being the Boxer and West Highland white terrier.
Journal ArticleDOI
An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Gräsbeck syndrome in dogs
John C. Fyfe,Shelby L. Hemker,Patrick J. Venta,Caitlin A. Fitzgerald,Catherine A. Outerbridge,Sherry L. Myers,Urs Giger +6 more
TL;DR: The border collie disorder indicates that a CUBN mutation far C-terminal from the intrinsic factor-cobalamin binding site can abrogate receptor expression and cause Imerslund-Gräsbeck syndrome.
References
More filters
Book
Introduction to quantitative genetics
TL;DR: The genetic constitution of a population: Hardy-Weinberg equilibrium and changes in gene frequency: migration mutation, changes of variance, and heritability are studied.
Journal Article
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
Journal ArticleDOI
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: The relationship between the two estimates of genetic variation at the DNA level, namely the number of segregating sites and the average number of nucleotide differences estimated from pairwise comparison, is investigated in this article.
Journal Article
Human biochemical genetics
TL;DR: For the next few weeks the course is going to be exploring a field that’s actually older than classical population genetics, although the approach it’ll be taking to it involves the use of population genetic machinery.
Journal ArticleDOI
A Map of Human Genome Variation From Population-Scale Sequencing
Gonçalo R. Abecasis,David Altshuler,David Altshuler,Adam Auton,Lisa D Brooks,Richard Durbin,Richard A. Gibbs,Matthew E. Hurles,Gil McVean +8 more
TL;DR: The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype as mentioned in this paper, and the results of the pilot phase of the project, designed to develop and compare different strategies for genomewide sequencing with high-throughput platforms.
Related Papers (5)
Genetic diversity, inbreeding and breeding practices in dogs: Results from pedigree analyses
Population structure and inbreeding from pedigree analysis of purebred dogs.
Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping
Amaury Vaysse,Abhirami Ratnakumar,Thomas Derrien,Erik Axelsson,Gerli Pielberg,Snaevar Sigurdsson,Tove Fall,Eija H. Seppälä,Mark Hansen,Cindy Lawley,Elinor K. Karlsson,Danika L. Bannasch,Carles Vilà,Hannes Lohi,Francis Galibert,Merete Fredholm,Jens Häggström,Åke Hedhammar,Catherine André,Kerstin Lindblad-Toh,Christophe Hitte,Matthew T. Webster +21 more