Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation [see comments]
Ernst Holler,Kolb Hj,A. Möller,J. Kempeni,S Liesenfeld,H Pechumer,W Lehmacher,G Ruckdeschel,B Gleixner,C Riedner +9 more
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This study suggests two pathways of TNF alpha release: activation of host macrophages and stimulation of donor cells in the course of acute graft-versus-host disease.About:
This article is published in Blood.The article was published on 1990-02-15 and is currently open access. It has received 574 citations till now. The article focuses on the topics: Tumor necrosis factor alpha & Bone marrow.read more
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Graft-Versus-Leukemia Effect of Donor Lymphocyte Transfusions in Marrow Grafted Patients
Hans-Jochem Kolb,A Schattenberg,JM Goldman,B Hertenstein,N Jacobsen,W Arcese,P Ljungman,A Ferrant,L Verdonck,D Niederwieser +9 more
TL;DR: Donor lymphocyte transfusions exert strong effects against myeloid forms of leukemia and induce durable remissions in CML.
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Donor Leukocyte Transfusions for Treatment of Recurrent Chronic Myelogenous Leukemia in Marrow Transplant Patients
Hans-Jochem Kolb,J. Mittermüller,Ch. Clemm,Ernst Holler,Georg Ledderose,G. Brehm,M.U. Heim,Wolfgang Wilmanns +7 more
TL;DR: Three patients with hematologic relapse after bone marrow transplantation for chronic myelogenous leukemia were treated with interferon alpha and transfusion of viable donor buffy coat and had complete hematological and cytogenetic remission, which persisted 32 to 91 weeks after treatment, an example of adoptive immunotherapy without cytoreductive chemotherapy or radiotherapy in human chimeras.
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An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation : I. The roles of minor H antigens and endotoxin
Kenneth R. Cooke,Lester Kobzik,Thomas R. Martin,Joanne P. Brewer,John Delmonte,James M. Crawford,James L.M. Ferrara +6 more
TL;DR: This murine BMT system is a potentially useful model of clinical IPS; minor H differences between donor and recipient can be important stimuli in the pathogenesis of IPS; and endotoxin in BAL fluid is associated with lung injury, and excess endotoxin can cause the development of alveolar hemorrhage in this model.
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Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema.
TL;DR: Systemic features in PRES appear to render strong support for the older theory of vasoconstriction coupled with hypoperfusion as the mechanism, including supporting evidence and current available imaging/clinical data related to the conditions that develop PRES.
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Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines
Geoffrey R. Hill,Geoffrey R. Hill,James M. Crawford,James M. Crawford,Kenneth R. Cooke,Kenneth R. Cooke,Yani S. Brinson,Yani S. Brinson,Luying Pan,Luying Pan,James L.M. Ferrara,James L.M. Ferrara +11 more
TL;DR: An increase in GVHD severity in several donor-recipient strain combinations after intensification of the conditioning regimen by increasing the total body irradiation (TBI) dose from 900 cGy to 1,300 cGy is shown.
References
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Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Kevin J. Tracey,Kevin J. Tracey,Yuman Fong,David G. Hesse,Kirk R. Manogue,Annette T. Lee,George C. Kuo,Stephen F. Lowry,Anthony Cerami +8 more
TL;DR: Protection against shock, vital organ dysfunction, persistent stress hormone release and death was conferred by administration of antibodies 2 h before bacterial infusion, indicating that cachectin is a mediator of fatal bacteraemic shock and suggesting that antibodies against Cachectin offer a potential therapy of life-threatening infection.
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Venoocclusive disease of the liver following bone marrow transplantation
Richard J. Jones,Kamthorn S. K. Lee,William E. Beschorner,Victor G. Vogel,Louise B. Grochow,Hayden G. Braine,Georgia B. Vogelsang,Lyle L. Sensenbrenner,George W. Santos,Rein Saral +9 more
TL;DR: VOD is a common complication of bone marrow transplantation and has a specific clinical presentation, which usually allows diagnosis without the need of liver biopsy, and is the third leading cause of death in allogeneic graft recipients, and the second leading cause in patients receiving autologous transplants.
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Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura.
TL;DR: Evidence is provided that serum levels of tumor necrosis factor alpha, interleukin-1, and gamma interferon correlate with the severity of meningococcemia in children, and the findings may have implications for new therapeutic approaches.
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Current concepts: immunology. Monocytes and macrophages.
TL;DR: Macrophages play a central and essential part in the immune response by presenting antigen to lymphocytes during the development of specific immunity and by serving as supportive, "accessory" cells...
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Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.
TL;DR: It is suggested that during acute GVHD, the activation of grafted lymphocytes leads to a local release of TNF in the cutaneous and intestinal mucosae, which induces epithelial cell alterations and increases the inflammatory reaction.