Journal ArticleDOI
Increasing effects of repetitive cocaine administration in the rat
Robert M. Post,Harvey Rose +1 more
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It is reported for the first time that repetitive cocaine administration can be associated with progressively increasing effects on horizontal and vertical hyperactivity as well as stereotypy in the rat.Abstract:
REPORTS of chronic cocaine (and related psychomotor stimulant) administration suggest that tolerance develops to many drug effects1–3. A few studies of high dose cocaine administration have suggested that, on the contrary, repetitive administration may be associated with increasing effects on cocaine-induced convulsions in the rat4,5 and monkey6 and increasing bizarre visual and inhibitory behaviour, as well as dyskinesias, in the monkey6. We now report for the first time that repetitive cocaine administration can be associated with progressively increasing effects on horizontal and vertical hyperactivity as well as stereotypy in the rat.read more
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Cellular and molecular mechanisms of drug dependence.
George F. Koob,Floyd E. Bloom +1 more
TL;DR: The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence.
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Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity
Peter W. Kalivas,Jane Stewart +1 more
TL;DR: It is found that the dopamine neurons of sensitized animals have become increasingly sensitive to excitatory pharmacological and environmental stimuli or desensitized to inhibitory regulation, and changes in cellular activity or protein synthesis may result in a change in the presynaptic regulation of axon terminal dopamine release.
Journal ArticleDOI
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli.
J. D. Jentsch,James Taylor +1 more
TL;DR: The neuro-anatomical and neurochemical substrates subserving inhibitory control and motivational processes in the rodent and primate brain and their putative impact on drug seeking are considered and an integrative hypothesis for compulsive reward-seeking in drug abuse is presented.
Journal ArticleDOI
The incentive sensitization theory of addiction: some current issues
TL;DR: The theory that addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems that attribute incentive salience to reward-associated stimuli is presented.
Journal ArticleDOI
A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
TL;DR: The present review examines the literature and critically evaluates the extent to which the neural consequences of repeated psychostimulant administration are associated with the expression of behavioral sensitization.
References
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Journal ArticleDOI
Modification of seizure activity by electrical stimulation. II. Motor seizure.
TL;DR: It was found that the development of motor seizures by stimulation of the amygdala resulted in an increased ability of the contralateral amygdala, and the septal area, but not of the hippocampus, to drive motor seizures when stimulated (“transfer”).
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A permanent change in brain function resulting from daily electrical stimulation.
TL;DR: High-intensity stimulation studies revealed that the development of convulsions was not based simply on threshold reduction, but involved complex reorganization of function.
Journal ArticleDOI
Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy
David S. Segal,Arnold J. Mandell +1 more
TL;DR: carry-over of both the post-injection augmentation and dark phase reduction of locomotion was revealed during amphetamine retest 8 days following discontinuation of daily d-amphetamine injections, indicating the importance of their concurrent evaluation, especially during chronic studies.
Journal ArticleDOI
Dopamine receptor binding: differentiation of agonist and antagonist states with 3H-dopamine and 3H-haloperidol.
TL;DR: 3H-Dopamine and 3H-haloperidol bind with high affinity and selectivity to synaptic dopamine receptors in membrane preparations of the calf caudate, and the rank-order of phenothiazines and related agents as well as catecholamines in displacing both dopamine and haloperidl binding closely parallels their pharmacological potencies and affinities for the dopamine-sensitive adenylate cyclase.
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