Journal ArticleDOI
Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line
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TLDR
In a neural cell line, the secretion of excitatory amino acids in response to a depolarizing stimulus is potentiated by the addition of serotonin, and inhibiting the NMDA receptor during serotonin presentation prevented the induction of potentiation.About:
This article is published in Neuron.The article was published on 1990-12-01. It has received 141 citations till now. The article focuses on the topics: Long-term potentiation & Serotonin.read more
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Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms.
TL;DR: Three structural requirements of flavonoids for protection from glutamate are the hydroxylated C3, an unsaturated C ring, and hydrophobicity, and three distinct mechanisms of protection are found, which show that the mechanism of protection from oxidative insults by flavonoid is highly specific for each compound.
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Cerium and yttrium oxide nanoparticles are neuroprotective.
TL;DR: It is shown here that nanoparticles composed of cerium oxide or yttrium oxide protect nerve cells from oxidative stress and that the neuroprotection is independent of particle size.
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Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures
Madalina Stanciu,Ying Wang,Ruth Kentor,Nancy V Burke,Simon C. Watkins,Geraldine J. Kress,Ian J. Reynolds,Eric Klann,Maria R. Angiolieri,Jon W. Johnson,Donald B. DeFranco +10 more
TL;DR: It is shown that delayed and persistent activation of ERKs is associated with glutamate-induced oxidative toxicity in HT22 cells and immature primary cortical neuron cultures, and that U0126, a specific inhibitor of the ERK-activating kinase, MEK-1/2, protects both HT22cells and immaturePrimary cortex neuron cultures from glutamate toxicity.
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A Role for 12-lipoxygenase in Nerve Cell Death Caused by Glutathione Depletion
TL;DR: Using immature cortical neurons and a clonal nerve cell line, it is shown that a decrease in GSH triggers the activation of neuronal 12-lipoxygenase (12-LOX), which leads to the production of peroxides, the influx of Ca2+, and ultimately to cell death.
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Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
Phoebe D. Lu,Céline Jousse,Stefan J. Marciniak,Yuhong Zhang,Isabel Novoa,Donalyn L Scheuner,Randal J. Kaufman,David Ron,Heather P. Harding +8 more
TL;DR: The findings indicate that eIF2α phosphorylation can initiate signaling in a cytoprotective gene expression pathway independently of other parallel stress‐induced signals and that activation of this pathway can single‐handedly promote a stress‐resistant preconditioned state.
References
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Journal ArticleDOI
Molecular Biology of Learning: Modulation of Transmitter Release.
Eric R. Kandel,James H. Schwartz +1 more
TL;DR: This review focuses primarily on short-term sensitization of the gill and siphon reflex in the marine mollusk, Aplysia californica, and analyses of this form of learning provide direct evidence that protein phosphorylation dependent on cyclic adenosine monophosphate can modulate synaptic action.
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Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
TL;DR: Both postsynaptic PKC and CaMKII are required for the induction of LTP and a presynaptic protein kinase appears to be necessary for the expression of L TP, and both post synapses and protein kinases are sensitive to externally applied H-7.
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Intracellular injections of EGTA block induction of hippocampal long-term potentiation
TL;DR: It is reported that intracellular injections of the calcium chelator EGTA block the development of LTP and this results strongly suggest that LTP is caused by a modification of the postsynaptic neurone and that its induction depends on the level of free calcium.
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Long-term potentiation.
T J Teyler,P DiScenna +1 more
TL;DR: The available evidence suggests that L TP does occur in conjunction with behavioral learning-although whether it is necessary and sufficient is far from certain.