Journal ArticleDOI
Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion.
TLDR
Although the theoretical percentage of CPM on aging remained fairly constant over the processing temperature ranges in this study, the HC levels remaining in the extruded films during storage were a function of time and temperature.Abstract:
Hydroxypropylcellulose (HPC) films containing drugs or hydrophilic or hydrophobic plasticizers were prepared by a hot melt extrusion process. Polyethylene glycol 8000 (PEG 8000) 2%, triethyl citrate (TEC) 2%, acetyltributyl citrate (ATBC) 2%, and polyethylene glycol 400 (PEG 400) 1% were the plasticizing agents studied. In addition, either hydrocortisone (HC) 1% or chlorpheniramine maleate (CPM) 1% was incorporated into the films as a model drug. The physical-mechanical properties of the films that were investigated included tensile strength (TS), percentage elongation (%E), and Young's modulus (YM). Differential scanning calorimetry (DSC) was utilized to determine glass transition temperatures (Tg' s). These parameters were studied as a function of time and temperature. The glass transition temperatures initially decreased with the inclusion of the drugs and plasticizers. However, after 6 months aging, films containing PEG 400 and HC showed a marked increase in Tg. The films containing PEG 400 showed phy...read more
Citations
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Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.
Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
Review: physical chemistry of solid dispersions
TL;DR: Thorough understanding of the physical chemistry and stability of glass solutions as they form supersaturated solutions, and during their shelf life will elicit conscious evaluation of carrier properties and eventually facilitate rational excipient selection.
Journal ArticleDOI
Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis
TL;DR: Combining calculation of Hansen solubility parameters with thermal analysis of drug/excipient miscibility can be successfully applied to predict formation of glass solutions with melt extrusion.
Journal ArticleDOI
Manufacture and characterization of mucoadhesive buccal films.
TL;DR: This review will consider the literature that describes the manufacture and characterization of mucoadhesive buccal films and hot-melt extrusion has been explored as an alternative manufacturing process and has yielded promising results.
References
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Journal ArticleDOI
Permeability and Mechanical Properties of Cellulose-Based Edible Films
TL;DR: In this article, the authors investigated factors affecting barrier properties and mechanical properties of methyl ccllulose (MC) and hydroxypropyl cellulose (HPC) films for both types of cellulose.
Journal ArticleDOI
Evaluation of hot-melt extrusion as a new technique for the production of polymer-based pellets for sustained release capsules containing high loadings of freely soluble drugs
TL;DR: In this paper, hot-melt screw extrusion was presented as an alternative method for producing polymer-based sustained release (SFL) pellets, which were produced with diltiazem hydrochloride as model drug.
Journal ArticleDOI
Hot melt extrusion of acrylic films
Journal ArticleDOI
Influence of Aging on the Physical-Mechanical Properties of Acrylic Resin Films Cast from Aqueous Dispersions and Organic Solutions
TL;DR: The physical-mechanical properties of the enteric copolymers, poly(methacrylic acid, ethyl acrylate) Eudragit® L100-55, and EudRAGIT® L30D have been investigated in this paper.
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