Journal ArticleDOI
Innervation of mammalian white adipose tissue: implications for the regulation of total body fat
TLDR
It is hypothesize that the SNS innervation of WAT is an important contributor to the apparent "regulation" of total body fat.Abstract:
We review the extensive physiological and neuroanatomical evidence for the innervation of white adipose tissue (WAT) by the sympathetic nervous system (SNS) as well as what is known about the sensory innervation of this tissue. The SNS innervation of WAT appears to be a part of the general SNS outflow from the central nervous system, consisting of structures and connections throughout the neural axis. The innervation of WAT by the SNS could play a role in the regulation of total body fat in general, most likely plays an important role in regional differences in lipid mobilization specifically, and may have a trophic affect on WAT. The exact nature of the SNS innervation of WAT is not known but it may involve contact with adipocytes and/or their associated vasculature. We hypothesize that the SNS innervation of WAT is an important contributor to the apparent “regulation” of total body fat.read more
Citations
More filters
Journal ArticleDOI
Adipocytes as regulators of energy balance and glucose homeostasis
TL;DR: Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways as discussed by the authors.
Journal ArticleDOI
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
Paul Trayhurn,John H. Beattie +1 more
TL;DR: The key challenges in establishing the secretory functions of white fat are to identify the complement of secreted proteins, to establish the role of each secreted protein, and to assess the pathophysiological consequences of changes in adipocyte protein production with alterations in adiposity.
Journal ArticleDOI
Multiple neural systems controlling food intake and body weight.
TL;DR: It is argued that processing within cortico-limbic areas and communication with hypothalamic areas are particularly important in human food intake control that is more and more guided by cognitive rather than metabolic aspects in the obesigenic environment of affluent societies.
Journal ArticleDOI
The biology of white adipocyte proliferation.
TL;DR: Together, these multiple regulatory controls orchestrate overall and region‐specific adipose tissue cellularity responses associated with the development of hyperplastic obesity.
Journal ArticleDOI
Ruminant Adaptation to Negative Energy Balance: Influences on the Etiology of Ketosis and Fatty Liver
TL;DR: In this article, failure of hepatic gluconeogenesis to supply adequate glucose for lactation and body needs may be one cause of ketosis; however, poor feedback control of nonesterified fatty acid release from adipose tissue is another likely cause of fat liver failure.
References
More filters
Journal ArticleDOI
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks.
TL;DR: The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance in ob/ob and diet-induced obese mice.
Journal ArticleDOI
Fluorescence of Catechol Amines and Related Compounds Condensed With Formaldehyde
TL;DR: In this article, the reaction between formaldehyde and phenylalanine and phenylethylamine derivatives has been studied under mild conditions and it has been shown that the amines primarily condense with formaldehyde to 1,2,3,4-tetrahydroisoquinolines which are involved in a secondary reaction to become highly fluorescent and at the same time insoluble.
Book
Biochemistry for the Medical Sciences
Eric A. Newsholme,A. R. Leech +1 more
TL;DR: This outstanding text, written in a clear, concise and easy-to-read style, provides students with an in-depth explanation of how each metabolic pathway is directly related to physiology, pharmacology, and clinical medicine.
Journal ArticleDOI
Insulin in the brain: a hormonal regulator of energy balance.
TL;DR: Recent investigations indicate that “brain insulin” is derived largely from the circulation, and a growing body of evidence suggests that its delivery into the neuropil may be facilitated by a specialized BBB barrier.