Journal ArticleDOI
Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA.
Alan A. Schreier,Paul Schimmel +1 more
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It is argued that the co-operative sites arise from the tRNA tertiary structure, and is further strengthened by the observation that cooperativity is present in a tRNAPhe molecule which has been split in the anticodon loop, but it is absent in oneWhich has beensplit in the extra loop.About:
This article is published in Journal of Molecular Biology.The article was published on 1974-07-05. It has received 92 citations till now. The article focuses on the topics: Cooperativity & Polynucleotide.read more
Citations
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Journal ArticleDOI
On the role of magnesium ions in RNA stability
Vinod K. Misra,David E. Draper +1 more
TL;DR: A picture of how magnesium stabilizes a particular folded form of RNA is presented and it is emphasized that diffuse binding can only be described rigorously by a model that accounts for long‐range electrostatic forces.
Journal ArticleDOI
The linkage between magnesium binding and RNA folding.
Vinod K. Misra,David E. Draper +1 more
TL;DR: A rigorous theoretical model describing the linkage between RNA folding and magnesium ion binding based on the non-linear Poisson-Boltzmann (NLPB) equation accurately describes both the stoichiometric and energetic linkage between Mg(2+) binding and RNA folding for both of these systems without requiring any fitted parameters in the calculation.
Journal ArticleDOI
Mechanism and kinetics of iron release from ferritin by dihydroflavins and dihydroflavin analogs
TL;DR: Several experiments fail to show any specific flavin binding site, though dihydroflavins do display saturation kinetics with very high apparent Km's, and rates of iron release show that the electron transfer is significantly rate determining in iron release by dihydroriboflavin, while diffusion of the di hydroflavin through the protein channel is slow in the release of iron by diHydroFMN.
Journal ArticleDOI
Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme
C. Ronald Geyer,Dipankar Sen +1 more
TL;DR: It is conceivable that substrate positioning, transition-state stabilization or general acid/base catalysis by the nucleic acid components of ribozymes and DNAzymes may contribute significantly to their overall catalytic performance.
Journal ArticleDOI
Role of counterion condensation in folding of the Tetrahymena ribozyme. I. Equilibrium stabilization by cations.
TL;DR: In this paper, the effects of counterion condensation upon the equilibrium folding of the Tetrahymena ribozyme were examined using a native gel electrophoresis assay, and a model for folding was proposed which predicts effects of charge, ionic radius and temperature on counterion-induced RNA folding transitions.
References
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Journal ArticleDOI
On the Nature of Allosteric Transitions: A Plausible Model
TL;DR: "It is certain that all bodies whatsoever, though they have no sense, yet they have perception, and whether the body be alterant or alterec, evermore a perception precedeth operation; for else all bodies would be like one to another."
Journal ArticleDOI
Comparison of experimental binding data and theoretical models in proteins containing subunits.
Journal ArticleDOI
The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.
Bruce N. Ames,Donald T. Dubin +1 more
TL;DR: The cations of T4 phage have been examined and a balance has been obtained between total cations and total DNA anions and the replacement of the normal polyamines suggested that the polyamines may be acting as nonspecific cations.
Book ChapterDOI
Linked functions and reciprocal effects in hemoglobin: a second look.
TL;DR: In this article, the authors discuss linked functions and reciprocal effects in hemoglobin and show that not only do the linkage relations apply irrespective of whether the macromolecules undergo chemical change or polymerization, but also whether the ligands themselves associate and dissociate, possibly as macromocules.