Journal ArticleDOI
On the Nature of Allosteric Transitions: A Plausible Model
TLDR
"It is certain that all bodies whatsoever, though they have no sense, yet they have perception, and whether the body be alterant or alterec, evermore a perception precedeth operation; for else all bodies would be like one to another."About:
This article is published in Journal of Molecular Biology.The article was published on 1965-05-01. It has received 8157 citations till now. The article focuses on the topics: Chemistry (relationship).read more
Citations
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Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.
Journal ArticleDOI
Selforganization of matter and the evolution of biological macromolecules
TL;DR: The causes and effect of cause and effect, and the prerequisites of Selforganization, are explained in more detail in the I.IA.
Journal ArticleDOI
Glycine potentiates the NMDA response in cultured mouse brain neurons
J. W. Johnson,P Ascher +1 more
TL;DR: G glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor, and can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
Journal ArticleDOI
Stereochemistry of cooperative effects in haemoglobin.
TL;DR: The oxygenation of haemoglobin is accompanied by structural changes in the subunits triggered by shifts of the iron atoms relative to the porphyrin and, in the β-subunits, also by the steric effect of oxygen itself.
References
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Journal ArticleDOI
Allosteric Proteins and Cellular Control Systems
TL;DR: The biological activity of many proteins is controlled by specific metabolites which do not interact directly with the substrates or products of the reactions, and it is suggested that this mechanism plays an essential role in the regulation of metabolic activity.
Journal ArticleDOI
Structure of Hæmoglobin: A Three-Dimensional Fourier Synthesis at 5.5-Å. Resolution, Obtained by X-Ray Analysis
Journal ArticleDOI
The Enzymology of Control by Feedback Inhibition
John C. Gerhart,Arthur B. Pardee +1 more
TL;DR: A feedback inhibition is investigated to learn more about its enzymological mechanism and it is shown that in the bacterium the activity of aspartate transcarbamylase is closely controlled by an end product, probably a cytosine de- rivative, and that inhibition of this enzyme is important for controlling the whole pathway.
Journal ArticleDOI
Teleonomic mechanisms in cellular metabolism, growth, and differentiation.
Jacques Monod,François Jacob +1 more
Book ChapterDOI
Assembly and Stability of the Tobacco Mosaic Virus Particle
TL;DR: The structural and physical chemical studies on TMV considered in this chapter provide a picture of the way in which the viral nucleic acid is packaged for transmission, and illustrate some general principles regarding the molecular organization of biological structures.