Intra- and multicenter reproducibility of pulsed, continuous and pseudo-continuous arterial spin labeling methods for measuring cerebral perfusion.
S. Gevers,Matthias J.P. van Osch,Reinoud P H Bokkers,Dennis A. Kies,Wouter M. Teeuwisse,Charles B. L. M. Majoie,Jeroen Hendrikse,Aart J. Nederveen +7 more
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TLDR
One could consider the use of reference values in clinical routine, with whole-brain p-CASL perfusion varying < 20% over repeated measurements within the same individuals considered to be normal, on the basis of the results of this study.Abstract:
Intra- and multicenter reproducibility of currently used arterial spin labeling (ASL) methods were assessed at three imaging centers in the Netherlands, equipped with Philips 3TMR scanners. Six healthy participants were scanned twice at each site. The imaging protocol consisted of continuous ASL (CASL), pseudo-continuous ASL (p-CASL) with and without background suppression, pulsed ASL (PASL) with single and multiple inversion times (TIs), and selective ASL for segmentation. Reproducibility was expressed in terms of the coefficient of repeatability and the repeatability index. Voxelwise analysis of variance was performed, yielding brain maps that reflected regional variability. Intra- and multicenter reproducibility were comparable for all methods, except for single TI PASL, with better intracenter reproducibility (F-test of equality of two variances, P<0.05). Pseudo-continuous ASL and multi TI PASL varied least between sites. Variability maps of all methods showed most variability near brain-feeding arteries within sessions and in gray matter between sessions. On the basis of the results of this study, one could consider the use of reference values in clinical routine, with whole-brain p-CASL perfusion varying <20% over repeated measurements within the same individuals considered to be normal. Knowledge on regional variability allows for the use of perfusion-weighted images in the assessment of local cerebral pathology.read more
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Journal ArticleDOI
Recommended Implementation of Arterial Spin Labeled Perfusion MRI for Clinical Applications: A consensus of the ISMRM Perfusion Study Group and the European Consortium for ASL in Dementia
David C. Alsop,John A. Detre,Xavier Golay,Matthias Günther,Jeroen Hendrikse,Luis Hernandez-Garcia,Hanzhang Lu,Bradley J. MacIntosh,Bradley J. MacIntosh,Laura M. Parkes,Marion Smits,Matthias J.P. van Osch,Danny J.J. Wang,Eric C. Wong,Greg Zaharchuk +14 more
TL;DR: This review provides a summary statement of recommended implementations of arterial spin labeling (ASL) for clinical applications and describes the major considerations and trade‐offs in implementing an ASL protocol and provides specific recommendations for a standard approach.
Journal ArticleDOI
Arterial Spin Labeling Perfusion of the Brain: Emerging Clinical Applications.
TL;DR: Current limitations and future developments of ASL techniques to improve clinical applicability, such as multiple inversion time ASL sequences to assess alterations of transit time, reproducibility and quantification of cerebral blood flow, and to measure cerebrovascular reserve, will be reviewed.
Journal ArticleDOI
Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: A head-to-head comparison with 15O H2O positron emission tomography
Dennis Heijtel,Henri J.M.M. Mutsaerts,Esther Bakker,Patrick Schober,M. F. Stevens,Esben Thade Petersen,B.N.M. van Berckel,Charles B. L. M. Majoie,Jan Booij,M.J.P. van Osch,Ed VanBavel,Ronald Boellaard,Adriaan A. Lammertsma,Aart J. Nederveen +13 more
TL;DR: It is demonstrated that pCASL CBF imaging is accurate during both baseline and hypercapnia with respect to (15)O H₂O PET with a comparable precision, paving the way for quantitative usage of pCasL MRI in both clinical and research settings.
Journal ArticleDOI
Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging.
Ke Zhang,Hans Herzog,Jörg Mauler,Christian Filss,Thomas W. Okell,Elena Rota Kops,Lutz Tellmann,Thomas Fischer,Burkhard Brocke,Walter Sturm,Heinz H. Coenen,Nadim Joni Shah +11 more
TL;DR: Using an integrated, hybrid MR-PET a direct simultaneous comparison between ASL and [15O]water PET became possible for the first time so that temporal, physiologic, and functional variations were avoided.
Journal ArticleDOI
Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: A systematic review.
TL;DR: The purpose of this work is to critically review studies that performed both [15O]-water positron emission tomography and arterial spin labeling to measure brain perfusion, with the aim of better understanding the accuracy and reproducibility of arterialspin labeling relative to the positron emit tomography reference standard.
References
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TL;DR: A general kinetic model for the ASL signal is described that can be used to assess systematic errors in arterial spin labeling techniques and provided a good description of pulsed ASL data during a simple sensorimotor activation task.
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Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields.
TL;DR: A new approach to continuous labeling that employs rapidly repeated gradient and radio frequency pulses to achieve continuous labeling with high efficiency is characterized and should help to realize the benefits of continuous labeling in clinical imagers.
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Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II)
TL;DR: Two modifications of pulsed ASL (QUIPSS and QUIPSS II) are introduced that avoid this problem by applying additional saturation pulses to control the time duration of the tagged bolus, rendering the technique relatively insensitive to transit delays and improving the quantitation of perfusion.
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