Intracellular Zinc Movement and Its Effect on the Carbohydrate Metabolism of Isolated Rat Hepatocytes
TLDR
The antagonistic action of zinc and cAMP on glycolysis together with the rapid and marked decrease in free zinc concentration induced by glucagon (cAMP) may indicate an as yet unknown role of zinc as an important mediator of regulation of carbohydrate metabolism.About:
This article is published in Journal of Biological Chemistry.The article was published on 1996-01-26 and is currently open access. It has received 84 citations till now. The article focuses on the topics: Glycogenolysis & Glycogen phosphorylase.read more
Citations
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Metallothionein: the multipurpose protein
TL;DR: Understanding of the multi-faceted role of MT is enhanced by use of mice with altered gene expression, emphasised in this review.
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Measurement of intracellular free zinc in living cortical neurons: routes of entry.
Stefano L. Sensi,Lorella M.T. Canzoniero,Shan Ping Yu,Howard S. Ying,Jae-Young Koh,Geoffrey A. Kerchner,Dennis W. Choi +6 more
TL;DR: Under conditions favoring reverse operation of the Na+–Ca2+ exchanger, Zn2+ application induced a slow increase in neurons and outward whole-cell current sensitive to benzamil–amiloride, suggesting that a second route of Zn 2+ entry into neurons may be via transporter-mediated exchange with intracellular Na+.
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Metallothionein Expression in Animals: A Physiological Perspective on Function
Steven R. Davis,Robert Cousins +1 more
TL;DR: Evidence has been produced, which suggests that metallothionein could act in a number of biochemical processes, including gene expression, apoptosis, proliferation and differentiation, and the ability of metallothsionein to exchange other metals with zinc in these proteins may explain a role in metal toxicity.
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Fluorescence analysis of the labile iron pool of mammalian cells.
TL;DR: The method provides a simple, noninvasive tool for on-line monitoring of cytosolic iron under normal and abnormal conditions of cell iron supply and for assessing the dynamics of intracellular iron in living cells.
References
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A new generation of Ca2+ indicators with greatly improved fluorescence properties.
TL;DR: A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+ using an 8-coordinate tetracarboxylate chelating site with stilbene chromophores that offer up to 30-fold brighter fluorescence.
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The biochemical basis of zinc physiology
TL;DR: Majors topics addressed in this review on zinc physiology are chemistry and biochemistry; interface of biochemistry and physiology of zinc; physiology and cell and molecular biology; and pathology.
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A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate.
TL;DR: A procedure allowing one to measure fructose 2,6-bisphosphate in amounts lower than a picomole, is described and the kinetic properties of the purified enzyme have been investigated.
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Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)
TL;DR: The results suggest that prevention of apoptosis is a function of labile Zn, and that a reduction below a threshold concentration in this Zn pool induces apoptosis.
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Hormonal Regulation of Hepatic Gluconeogenesis and Glycolysis
TL;DR: MODULATION of the PHOSPHORYLATION STATE of KEY REGULATORY HEPATIC ENZyMES .