Journal ArticleDOI
Intravenous Droperidol or Olanzapine as an Adjunct to Midazolam for the Acutely Agitated Patient: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Esther W. Chan,David Taylor,Jonathan C Knott,Georgina Phillips,David J. Castle,David C. M. Kong +5 more
Reads0
Chats0
TLDR
Intravenous droperidol or olanzapine as an adjunct to midazolam is effective and decreases the time to adequate sedation compared with midazlam alone.About:
This article is published in Annals of Emergency Medicine.The article was published on 2013-01-01. It has received 101 citations till now. The article focuses on the topics: Droperidol & Sedation.read more
Citations
More filters
Journal ArticleDOI
Assessment and management of agitation in psychiatry: Expert consensus
Marina Garriga,Isabella Pacchiarotti,Siegfried Kasper,Scott L. Zeller,Michael H. Allen,Gustavo H. Vázquez,Leonardo Baldaçara,Luis San,R. Hamish McAllister-Williams,Konstantinos N. Fountoulakis,Philippe Courtet,Dieter Naber,Esther W. Chan,Andrea Fagiolini,Hans-Jürgen Möller,Heinz Grunze,Pierre-Michel Llorca,Richard L Jaffe,Lakshmi N. Yatham,Diego Hidalgo-Mazzei,Marc Passamar,Thomas Messer,Miquel Bernardo,Eduard Vieta +23 more
TL;DR: Recommendations on the assessment of agitation emphasise the importance of identifying any possible medical cause and the “ideal” medication should calm without over-sedate.
Journal ArticleDOI
The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioral Disturbance in the Emergency Department.
Leonie Calver,Colin B. Page,Michael A. Downes,Betty S. Chan,Frances Kinnear,Luke Wheatley,David A. Spain,Geoffrey K. Isbister +7 more
TL;DR: The study supports the use of high-dose droperidol as a safe sedating agent for patients with acute behavioral disturbance in the ED and shows no evidence of increased risk for QT prolongation with the doses used in this study.
Journal ArticleDOI
Midazolam-droperidol, droperidol, or olanzapine for acute agitation: a randomized clinical trial
David Taylor,Celene Y. L. Yap,Jonathan C Knott,Simone E Taylor,Georgina Phillips,Jonathan Karro,Esther W. Chan,David Cm Kong,David J. Castle +8 more
TL;DR: Midazolam‐droperidol combination therapy is superior, in the doses studied, to either dro peridol or olanzapine monotherapy for intravenous sedation of the acutely agitated ED patient.
Journal ArticleDOI
The Characteristics and Prevalence of Agitation in an Urban County Emergency Department
TL;DR: Agitated patients frequently required restraint and sedation, with significant rates of clinical events requiring intervention, and characteristics associated with a clinical event included delirium symptoms.
Journal ArticleDOI
Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation in the Emergency Department.
Lauren R. Klein,Brian E. Driver,James R. Miner,Marc L. Martel,Michelle Hessel,Jacob D. Collins,Gabriella B. Horton,Erik Fagerstrom,Rajesh Satpathy,Jon B. Cole +9 more
TL;DR: Intramuscular midazolam achieved more effective sedation in agitated ED patients at 15 minutes than haloperidol, ziprasidone, and perhaps olanzapine.
References
More filters
Journal ArticleDOI
Haloperidol, lorazepam, or both for psychotic agitation? A multicenter, prospective, double-blind, emergency department study
John Battaglia,Sue Moss,John Rush,Jasbir Kang,Ricardo Mendoza,Liane J. Leedom,William R. Dubin,Charles McGlynn,Lowell Goodman +8 more
TL;DR: The superior results produced by the combination treatment support the use of lorazepam plus haloperidol as the treatment of choice for acute psychotic agitation.
Journal ArticleDOI
Pharmacological Management of Acute Agitation
TL;DR: Current clinical experience and one naturalistic study with intramuscular ziprasidone suggest that it is efficacious and can be safely used in patients with known QTc interval-associated conditions, and these atypical antipsychotics may represent a historical advance in the treatment of acute agitation.
Journal ArticleDOI
Droperidol versus haloperidol for chemical restraint of agitated and combative patients
TL;DR: In equal IM doses (5 mg), droperidol results in more rapid control of agitated patients than haloperidol, without any increase in undesirable side effects.
Journal ArticleDOI
Rapid tranquillisation of violent or agitated patients in a psychiatric emergency setting. Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus promethazine.
TL;DR: Both interventions are effective for controlling violent/agitated behaviour and if speed of sedation is required, the haloperidol-promethazine combination has advantages over lorazepam.
Journal ArticleDOI
Sedative and analgesic medications: risk factors for delirium and sleep disturbances in the critically ill.
TL;DR: O Ongoing clinical trials should help us to understand whether altering the delivery strategy, via daily sedation interruption, or protocolized target-based sedation or changing sedation paradigms to target different central nervous system receptors can affect cognitive outcomes and sleep preservation in critically ill patients.