Journal ArticleDOI
Investigating the possible pain attenuating mechanisms of pregabalin in chronic constriction injury-induced neuropathic pain in rats.
Reads0
Chats0
TLDR
Pregabalin may increase the release of nitric oxide, which may increaseThe release of endogenous opioids to attenuate neuropathic pain in CCI subjected rats.Abstract:
Aim of the study: The current study was aimed to investigate the neuropathic pain attenuating mechanism of pregabalin using chronic constriction injury (CCI) model in rats.Material and Meth...read more
Citations
More filters
Journal ArticleDOI
Exploring the role and mechanisms of diallyl trisulfide and diallyl disulfide in chronic constriction-induced neuropathic pain in rats.
TL;DR: Diallyl disulfide and diallyl trisulfide have the potential to attenuate neuropathic pain in CCI-subjected rats possibly through activation of H2S-BDNF-Nrf2 signaling pathway.
Journal ArticleDOI
The Ameliorative Effect of Thymoquinone on Vincristine-Induced Peripheral Neuropathy in Mice by Modulating Cellular Oxidative Stress and Cytokine
TL;DR: In this article , Thymoquinone (TQ) has been reported to exert a broad spectrum of pharmacological effects, including neuroprotective, anticancer, anti-inflammatory, antidiabetic, antiepileptic, antioxidant, and other modulatory roles in inflammation.
References
More filters
Journal ArticleDOI
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.
Gary J. Bennett,Y.-K. Xie +1 more
TL;DR: A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve and the postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain were produced.
Journal ArticleDOI
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
Nanna B. Finnerup,Nadine Attal,Simon Haroutounian,Ewan D McNicol,Ralf Baron,Robert H. Dworkin,Ian Gilron,Maija Haanpää,Per Hansson,Per Hansson,Troels S. Jensen,Troels S. Jensen,Peter R. Kamerman,Karen Lund,Andrew Moore,Srinivasa N. Raja,Andrew S.C. Rice,Andrew S.C. Rice,Michael C. Rowbotham,Emily S. Sena,Emily S. Sena,Philip J. Siddall,Philip J. Siddall,Blair H. Smith,Mark S. Wallace +24 more
TL;DR: The results support a revision of the NeuPSIG recommendations for the pharmacotherapy of neuropathic pain and allow a strong recommendation for use and proposal as first-line treatment in neuropathicPain for tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors, pregabalin, and gabapentin.
Journal ArticleDOI
Neuropathic pain Redefinition and a grading system for clinical and research purposes
Rolf-Detlef Treede,Troels S. Jensen,James N. Campbell,Giorgio Cruccu,Jonathan O. Dostrovsky,J. W. Griffin,Per Hansson,Richard A. C. Hughes,Turo Nurmikko,Jordi Serra +9 more
TL;DR: A grading system of definite, probable, and possible neuropathic pain is proposed, which includes the grade possible, which can only be regarded as a working hypothesis, and the grades probable and definite, which require confirmatory evidence from a neurologic examination.
Journal ArticleDOI
Neuropathic pain: redefinition and a grading system for clinical and research purposes.
TL;DR: The clinical resemblance between patients with and without evidence of disease has been taken to indicate that both profiles are neuropathic, but the second profile is not.
Journal ArticleDOI
Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
TL;DR: The results of the present study suggest that the animal model exhibits neuropathic pain behaviors including ongoing pain, heat hyperalgesia, mechanical allodynia and cold allodynian and that this model represents a model for sympathetically maintained pain.