Journal ArticleDOI
Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats.
Muthukumaran Jayachandran,Ziyuan Wu,Kumar Ganesan,Sumbul Khalid,Stephen Sum Man Chung,Baojun Xu +5 more
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TLDR
The results of this study provided convincing evidence of significant pharmacological properties of isoquercetin in context of its ability to inhibit the oxidative stress elicited by the STZ through generation of the free radicals and regulation of the expression of Nrf2 pathway-associated proteins and genes and it also reduced the burden of hyperlipidemia and inflammation.About:
This article is published in Chemico-Biological Interactions.The article was published on 2019-04-25. It has received 44 citations till now. The article focuses on the topics: Isoquercetin & AMPK.read more
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Journal ArticleDOI
Anti-Fungal Efficacy and Mechanisms of Flavonoids.
TL;DR: This review focuses on various naturally occurring flavonoids and their antifungal activities, modes of action, and synergetic use in combination with conventional drugs.
Journal ArticleDOI
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
Lucas Opazo-Ríos,Sebastian Mas,Gema Marín-Royo,Sergio Mezzano,Carmen Gomez-Guerrero,Juan Antonio Moreno,Jesús Egido +6 more
TL;DR: This review examines the recent preclinical and clinical research about the potentially harmful effects of lipid effects in the kidney, metabolic markers associated with these mechanisms, major signaling pathways affected, the causes of excessive lipid accumulation, and the types of lipids involved, as well as offers a comprehensive update of therapeutic strategies targeting lipotoxicity.
Journal ArticleDOI
Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides
Kumar Ganesan,Baojun Xu +1 more
TL;DR: Dietary polysaccharides can effectively ameliorate hyperglycemia, hyperlipidemia, low-grade inflammation, and oxidative stress in type 2 diabetes mellitus (T2DM), and, thus, consumption of poly Saccharide can be a valuable choice for diabetic control.
Journal ArticleDOI
The Coming Age of Flavonoids in the Treatment of Diabetic Complications
Teresa Caro-Ordieres,Gema Marín-Royo,Lucas Opazo-Ríos,Luna Jimenez-Castilla,Juan Antonio Moreno,Carmen Gomez-Guerrero,Jesús Egido +6 more
TL;DR: Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.
Journal ArticleDOI
Diet-Derived Phytochemicals Targeting Colon Cancer Stem Cells and Microbiota in Colorectal Cancer
TL;DR: Diet-derived phytochemicals modulate the microbiome as well as targeting colon cancer stem cells (CSCs) that are found to offer significant protective effects against CRC, which could be a promising and efficient way to reduce the burden of CRC.
References
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Journal ArticleDOI
Selenium: Biochemical Role as a Component of Glutathione Peroxidase
TL;DR: When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.
Journal ArticleDOI
A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.
Roland F. Beers,Irwin W. Sizer +1 more
TL;DR: A quantitative, spectrophotometric technique for following the breakdown of hydrogen peroxide has been developed for routine studies of catalase kinetics and appears to give lower values forCatalase activity than do titration techniques.
Journal ArticleDOI
Oxidative Stress, Inflammation, and Cancer: How Are They Linked?
TL;DR: Observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.
Journal ArticleDOI
A simple method for clinical assay of superoxide dismutase.
Yi Sun,L. W. Oberley,Ying Li +2 more
TL;DR: The Cu,ZnSOD concentrations in serum and plasma of patients with cancer of the large intestine tended to be less and greater than these values, respectively, but not statistically significantly so.
Book ChapterDOI
Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids
TL;DR: This chapter discusses selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids and suggests that prompt stabilization is especially important in the case of plasma or serum.
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