Journal ArticleDOI
Karyopherin-mediated nucleocytoplasmic transport
TLDR
Current knowledge of the import and export of the components of three large gene expression machines - the core replisome, RNA polymerase II and the ribosome - is described, pointing out the questions that persist about how such large macromolecular complexes are trafficked to serve their function in a designated subcellular location.About:
This article is published in Nature Reviews Molecular Cell Biology.The article was published on 2022-01-20. It has received 56 citations till now. The article focuses on the topics: Medicine & Karyopherin.read more
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Journal ArticleDOI
Function of the Nuclear Transport Machinery in Maintaining the Distinctive Compositions of the Nucleus and Cytoplasm
TL;DR: Although the separation of transcription and translation, mediated by the nuclear envelope, is the defining characteristic of Eukaryotes, the barrier between the nuclear and cytoplasmic compartments needs to be semipermeable to enable material to be moved between them.
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Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology
TL;DR: In this article , the authors comprehensively discuss history and recent advances in targeted therapies on organelles, specifically including nucleus, mitochondria, lysosomes and endoplasmic reticulum, while focusing on organelle structures, organelle-mediated cell death signal pathways, and design guidelines of organelle targeted nanomedicines based on intervention mechanisms.
Journal ArticleDOI
Solving the nuclear pore puzzle
TL;DR: Bley et al. as mentioned in this paper used a battery of tools to reveal the architecture of the nuclear pore complex (NPC) in eukaryotic cells, and they provided molecular structures, in unprecedented detail, of how NPCs are built.
Journal ArticleDOI
Differential nuclear import sets the timing of protein access to the embryonic genome
TL;DR: In this paper , the authors find that in early embryonic development access of maternally deposited nuclear proteins to the genome is temporally ordered via importin affinities, thereby timing the expression of downstream targets.
Journal ArticleDOI
Quality control mechanisms that protect nuclear envelope identity and function
Philip Mannino,C. Patrick Lusk +1 more
TL;DR: The most recent work exploring nuclear envelope quality control mechanisms across eukaryotes is synthesized, finding specializations of cellular degradative machineries tailored to meeting the unique challenges imposed by the NE.
References
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PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization.
Kenta Nakai,Paul Horton +1 more
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The economics of ribosome biosynthesis in yeast.
TL;DR: In a rapidly growing yeast cell, 60% of total transcription is devoted to ribosomal RNA, and 50% of RNA polymerase II transcription and 90% of mRNA splicing are devoted to Ribosomal proteins (RPs).
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A knowledge base for predicting protein localization sites in eukaryotic cells
Kenta Nakai,Minoru Kanehisa +1 more
TL;DR: An expert system is reported for predicting localization sites of proteins only from the information on the amino acid sequence and the source origin, which is powerful and flexible enough to be used in genome analyses.
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Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence
TL;DR: Point mutagenesis of the nuclear targeting sequence of nucleoplasmin has identified two interdependent basic domains separated by 10 intervening "spacer" amino acids that tolerate point mutations and some insertions.
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The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.
TL;DR: These results indicate that the HIV-1 rev gene product induces HIV- 1 structural gene expression by activating the sequence-specific nuclear export of incompletely spliced HIV-2 RNA species.