Journal ArticleDOI
Kava lactones and the kava-kava controversy.
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TLDR
The Michael reaction between glutathione and kava lactones, resulting in opening of the lactone ring, reduces the side effects of the kava kava extracts and recommends made for safe usage of kava-kava products.About:
This article is published in Phytochemistry.The article was published on 2003-10-01. It has received 137 citations till now. The article focuses on the topics: Piper methysticum & Yangonin.read more
Citations
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Chromatographic separation techniques and data handling methods for herbal fingerprints: a review.
TL;DR: The evolution of the regulations and guidelines on the quality control of herbal medicines is considered, and the established analytical techniques for herbal fingerprinting are reviewed with an emphasis on the most recent developments, such as miniaturized techniques, new stationary phases, analysis at high temperatures and multi-dimensional chromatography.
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In Vivo Effects of Goldenseal, Kava Kava, Black Cohosh, and Valerian on Human Cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 Phenotypes
Bill J. Gurley,Bill J. Gurley,Stephanie F. Gardner,Stephanie F. Gardner,Martha A. Hubbard,Martha A. Hubbard,D. Keith Williams,D. Keith Williams,W. Brooks Gentry,W. Brooks Gentry,Ikhlas A. Khan,Ikhlas A. Khan,Amit K Shah,Amit K Shah +13 more
TL;DR: Single‐time point phenotypic metabolic ratios were used to determine whether long‐term supplementation of goldenseal, black cohosh, kava kava, or valerian extracts affected CYP1A2, CYD2D6, CYP2E1, or CYP3A4/5 activity.
Journal ArticleDOI
Drug-induced hepatotoxicity: 2005.
TL;DR: The spectrum of drug-induced liver injury is broad with simulation of almost all unknown liver disorders as mentioned in this paper, and drug-drug interactions present particular problems in patients, often elderly, who are receiving several drugs simultaneously.
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Kava: A Comprehensive Review of Efficacy, Safety, and Psychopharmacology
TL;DR: The current weight of evidence supports the use of kava in treatment of anxiety with a significant result occurring in four out of six studies reviewed, and more studies are required to assess comparative efficacy and safety versus established pharmaceutical comparators.
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Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways
Ping Zhou,Ping Zhou,Shimon Gross,Ji Hua Liu,Bo Yang Yu,Ling Ling Feng,Jan A. Nolta,Jan A. Nolta,Vijay Sharma,David Piwnica-Worms,Samuel X. Qiu +10 more
TL;DR: Flavokawain B (FKB), a chalcone from kava root, is a potent GSH-sensitive hepatotoxin, levels of which should be specifically monitored and controlled in kava-containing herb products.
References
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Journal ArticleDOI
Glutathione in Health and Disease: Pharmacotherapeutic Issues:
Ben M. Lomaestro,Margaret Malone +1 more
TL;DR: A basic overview of the widespread use and interest in glutathione therapy is provided and clinicians are introduced to what GSH is, its basic chemistry, and some areas of active research.
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Hepatitis associated with Kava, a herbal remedy for anxiety
TL;DR: A 50 year old man presented to his doctor because of jaundice, having noticed fatigue for a month, a “tanned” skin, and dark urine, and the medical history was unremarkable.
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Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise.
TL;DR: It is shown that glutathione homeostasis is largely maintained in the cochlea and that biochemical changes, if they occur under these conditions, may be limited to specific cells.
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Glutathione protection against gentamicin ototoxicity depends on nutritional status.
TL;DR: The results suggest that gentamicin toxicity and detoxifying mechanisms are affected by the metabolic state of the animal and the glutathione content of the tissue and compounds that could potentially protect against Gentamicin ototoxicity may be more correctly assessed in animal models of deficient nutritional states in which endogenous detoxification mechanisms are compromised.
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The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells
TL;DR: Results can be explained by the different reactivity and equilibrium conditions for thiol addition of the two reactive centers of bifunctional STLs in cellular test systems and verified a clear correlation between the different reactsivity of their electrophilic centers and the observed biological effects in in-vitro cell systems.