Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19
Denise Battaglini,Miquéias Lopes-Pacheco,Hugo C. Castro-Faria-Neto,Paolo Pelosi,Patricia R. M. Rocco +4 more
TLDR
A narrative review aims to identify laboratory biomarkers that have shown significant diagnostic and prognostic value for risk stratification in COVID-19 and discusses the possible clinical application of novel analytic strategies, like metabolomics and proteomics.Abstract:
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes a wide spectrum of clinical manifestations, with progression to multiorgan failure in the most severe cases. Several biomarkers can be altered in coronavirus disease 2019 (COVID-19), and they can be associated with diagnosis, prognosis, and outcomes. The most used biomarkers in COVID-19 include several proinflammatory cytokines, neuron-specific enolase (NSE), lactate dehydrogenase (LDH), aspartate transaminase (AST), neutrophil count, neutrophils-to-lymphocytes ratio, troponins, creatine kinase (MB), myoglobin, D-dimer, brain natriuretic peptide (BNP), and its N-terminal pro-hormone (NT-proBNP). Some of these biomarkers can be readily used to predict disease severity, hospitalization, intensive care unit (ICU) admission, and mortality, while others, such as metabolomic and proteomic analysis, have not yet translated to clinical practice. This narrative review aims to identify laboratory biomarkers that have shown significant diagnostic and prognostic value for risk stratification in COVID-19 and discuss the possible clinical application of novel analytic strategies, like metabolomics and proteomics. Future research should focus on identifying a limited but essential number of laboratory biomarkers to easily predict prognosis and outcome in severe COVID-19.read more
Citations
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COVID-19 and the antiphospholipid syndrome
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Personalized medicine using omics approaches in acute respiratory distress syndrome to identify biological phenotypes
Denise Battaglini,Lou’i Al-Husinat,Ana Gabriela Costa Normando,Adriana Franco Paes Leme,Kleber G. Franchini,Marcelo M. Morales,Paolo Pelosi,Patricia R. M. Rocco +7 more
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C-Reactive Protein (CRP): A poor prognostic biomarker in COVID-19
Mohamed Zakaria Bouayed,Ilyas Laaribi,Charaf Eddine Mohammed Chatar,Ilias Benaini,Mohammed-Amine Bouazzaoui,Younes Oujidi,Samia Berrichi,G. El aidouni,Houssam Bkiyar,Naima Abda,Brahim Housni +10 more
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Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid Treatment
Matt Spick,A. Campbell,Ivona Baricevic-Jones,Johanna von Gerichten,Holly-May Lewis,Cecile Frampas,Katherine Longman,Alexander J. Stewart,Deborah K. Dunn-Walters,Debra J. Skene,Nophar Geifman,Anthony D. Whetton,Melanie J. Bailey +12 more
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Discrepancy between biomarkers of lung injury and 1‐year mortality in COVID‐19
TL;DR: This cross‐sectional and observational study evaluated the associations between the biomarkers, COVID‐19 pneumonia severity and 1‐year mortality and found no relationship between biomarkers and mortality.
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