Journal ArticleDOI
Laboratory methods and quality assurance in the Cardiovascular Health Study.
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TLDR
Results of quality-assurance analyses used to resolve problems were successful, thereby improving the second laboratory examination, and improving the first examination period.Abstract:
The Cardiovascular Health Study is an observational cohort study of risk factors for cardiovascular disease in 5201 participants, ages > or = 65 years. We report the methods and quality-assurance results for blood procurement, processing, shipping, storage, and sample analysis used during the first examination period (May 1989-June 1990). The most frequent difficulty in phlebotomy and processing was the requirement of more than one venipuncture (in 2.6% of the participants). The CVs for control materials ranged from 0.93% for glucose to 10.7% for insulin; most were < 4%. In addition to standard quality-assurance methods, we applied two other methods: technical error calculation for replicates, and weighted linear regression to assess time trend in results of control materials. After outliers were excluded, technical error values ranged from 1.7 for uric acid to 18.8 for insulin. Factor VII and factor VIII had slight trends over the 12-month analysis period. Results of quality-assurance analyses used to resolve problems were successful, thereby improving the second laboratory examination.read more
Citations
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Journal ArticleDOI
Incidence of and Risk Factors for Atrial Fibrillation in Older Adults
Bruce M. Psaty,Teri A. Manolio,Lewis H. Kuller,Richard A. Kronmal,Mary Cushman,Linda P. Fried,Richard H. White,Curt D. Furberg,Pentti M. Rautaharju +8 more
TL;DR: The incidence of AF in older adults may be higher than estimated by previous population studies and left atrial size appears to be an important risk factor, and the control of blood pressure and glucose may be important in preventing the development of AF.
Journal ArticleDOI
Cystatin C and the risk of death and cardiovascular events among elderly persons.
Michael G. Shlipak,Mark J. Sarnak,Ronit Katz,Linda F. Fried,Stephen L. Seliger,Anne B. Newman,David S. Siscovick,Catherine Stehman-Breen +7 more
TL;DR: Cystatin C, a serum measure of renal function, is a stronger predictor of the risk of death and cardiovascular events in elderly persons than is creatinine.
Journal ArticleDOI
Risk Factors for 5-Year Mortality in Older Adults The Cardiovascular Health Study
Linda P. Fried,Richard A. Kronmal,Anne B. Newman,Diane E. Bild,Maurice B. Mittelmark,Joseph F. Polak,John A Robbins,Julius M. Gardin +7 more
TL;DR: Objective measures of subclinical disease and disease severity were independent and joint predictors of 5-year mortality in older adults, along with male sex, relative poverty, physical activity, smoking, indicators of frailty, and disability.
Journal ArticleDOI
The reasons for geographic and racial differences in stroke study: objectives and design.
Virginia J. Howard,Mary Cushman,LeaVonne Pulley,Camilo R. Gomez,Rodney C.P. Go,Ronald J. Prineas,Andra Graham,Claudia S. Moy,George Howard +8 more
TL;DR: The novel aspects of the REGARDS study allow for the creation of a national cohort to address geographic and ethnic differences in stroke.
Journal ArticleDOI
Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly Results From the Cardiovascular Health Study and the Rural Health Promotion Project
Russell P. Tracy,Rozenn N. Lemaitre,Bruce M. Psaty,Diane G. Ives,Rhobert W. Evans,Mary Cushman,Elaine N. Meilahn,Lewis H. Kuller +7 more
TL;DR: It is shown that CRP was associated with incident events in the elderly, especially in those with subclinical disease at baseline, and in women but not men, the mean CRP level was higher for case subjects than for control subjects.
References
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Journal ArticleDOI
The cardiovascular health study: Design and rationale
Linda P. Fried,Nemat O. Borhani,Paul L. Enright,Curt D. Furberg,Julius M. Gardin,Richard A. Kronmal,Lewis H. Kuller,Teri A. Manolio,Maurice B. Mittelmark,Anne B. Newman,Daniel H. O'Leary,Bruce M. Psaty,Pentti M. Rautaharju,Russell P. Tracy,Philip G. Weiler +14 more
TL;DR: These examinations in CHS permit evaluation of CVD risk factors in older adults, particularly in groups previously under-represented in epidemiologic studies, such as women and the very old.
Journal ArticleDOI
Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
DeWitt S. Goodman,Stephen B. Hulley,Luther T. Clark,Clay Davis,Valentin Fuster,John C. LaRosa,Albert Oberman,Ernst J. Schaefer,Daniel Steinberg,W. Virgil Brown,Scott M. Grundy,Diane M. Becker,Edwin L. Bierman,Jacqueline Sooter-Bochenek,Rebecca M. Mullis,Neil J. Stone,Donald B. Hunninghake,Jacqueline M. Dunbar,Henry N. Ginsberg,D. Roger Illingworth,Harold C. Sadin,Gustav Schonfeld,James I. Cleeman,H. Bryan Brewer,Nancy D. Ernst,William T. Friedewald,Jeffrey M. Hoeg,Basil M. Rifkind,David L. Gordon +28 more
TL;DR: New guidelines for the treatment of high blood cholesterol in adults 20 years of age and over are provided and which patients should go on to have lipoprotein analysis, and which should receive cholesterol-lowering treatment on the basis of their low density lipop protein levels and status with respect to other coronary heart disease risk factors are detailed.
Journal ArticleDOI
ARIC hemostasis study--I. Development of a blood collection and processing system suitable for multicenter hemostatic studies.
TL;DR: It is concluded that the described blood collection and processing system may be a valuable asset for conducting multicenter cooperative clinical trials and epidemiologic studies involving blood collection by multiple field centers or clinics.
Journal ArticleDOI
Assessment of the reliability of physical measures
TL;DR: Assessment of the reliability of physical measures that yield continuous data should include the following statistics and procedures: mean, minimal and maximal differences; standard deviation of the net differences; technical error of measurement; and clinically meaningful indices of agreement.